- Duración
- 01/12/2020 - 28/02/2022
- Coordinador
- Jeffrey Lazarus
- Financiadores
- Gilead Sciences HBV-CARE Programme
Hepatitis B infection is a major global health burden, which, if left untreated, can lead to liver cirrhosis, hepatocellular carcinomas (HCC), and death. There are an estimated 248 million people living with chronic hepatitis B and the number continues to rise. Only 10.5% of those with hepatitis B virus (HBV) were thought to be aware of their status in 2016. WHO has called for its elimination as a public health threat by 2030.
Photo: Jan Pilarcik
The objective of this study is to use point-of-care diagnostics in community and faith-based settings to identify and link to care African (Ghanaian and Senegalese who are living in the greater Barcelona area) migrants living with HBV. Specifically, this pilot study utilizes a novel rapid diagnostic test to screen for HBsAg, the dried plasma spot testing method to collect blood samples and transport them to the laboratory, and will offer decentralized vaccination when appropriate for those who do not already have immunity.
Photo: Jan Pilarcik
Participants are screened in community centers on a pre-determined day arranged through community health agents. Before the screening process, an information session on HBV is provided by the community health agents, including the use of the HeparJoc interactive tool co-created with migrant populations.
Photo: Jan Pilarcik
Positive cases are provided with referrals to one of the two collaborating university hospitals in Barcelona during this first visit, irrespective of their viral load, for confirmation of infection and treatment initiation if applicable. Negative cases are provided their results during a second visit on average three weeks after the initial screening. Those who are negative and with no resolved past infection are offered the first-dose of the HBV vaccine in situ, with a referral for the subsequent doses at their corresponding primary care centers.
Photo: Jan Pilarcik
Photo: Jan Pilarcik
The project was launched in November 2020 and is led by ISGlobal in collaboration with west African community members, Hospital Clínic de Barcelona, Hospital Universitari Vall d'Hebron, the Health Department of the Generalitat de Catalunya, the Public Health Agency of Barcelona, and the Microbiology Department of the Vall d'Hebron Research Institute (VHIR).
Photo: Jan Pilarcik
Published papers
Picchio, CA., Nomah, DK., Araujo, SG. et al. A novel model of care for simplified testing of HBV in African communities during the COVID-19 pandemic in Spain. Sci Rep 11, 17063 (2021). https://www.nature.com/articles/s41598-021-96350-3.
Published abstracts
- Picchio CA, Fernández E, Araujo SG, et al. Decentralized HBV vaccination in west African community centres in greater Barcelona, Spain, to accelerate viral hepatitis elimination: preliminary data from the HBV-COMSAVA model of care. Conference on Liver Diseases in Africa (COLDA), virtual (2021).
- Picchio CA, Nomah DK, Rando-Segura A et al. HBV-COMSAVA: Preliminary results from a novel community-based hepatitis B screening and linkage to care programme for west African migrants in greater Barcelona, Spain. Global Hepatitis Summit, Taipei [Hybrid due to COVID-19] (2021).
- Picchio CA, Nomah DK, Rando-Segura A et al. Simplifiación del cribado de hepatitis B en Cataluña en población migrante procedente de África occidental: datos preliminares del modelo de cuidado HBV-COMSAVA. Asociación Española del Estudio del Higado (AAEH) Congreso, Madrid (2021).
- Picchio CA, Buti M, Kwakye Nomah D, Villota M, Lens S, Mandas M, Majó X, Colom J, Lazarus JV. Eliminating hepatitis B virus infection in west African migrants in Barcelona: a community-based testing and vaccination model of care to link patients to liver specialists. International Viral Hepatitis Elimination Meeting (IVHEM), Amsterdam [Virtual due to COVID-19] (2020).
- Picchio CA, Kwakye Nomah D, Lazarus JV. HBV awareness and self-reported testing and vaccination in Ghanaian migrants living in the greater Barcelona area participating in a community-based intervention. Conference on Liver Diseases in Africa (COLDA), Dakar [Virtual due to COVID-19] (2020).
Nuestro equipo
Coordinator
- Jeffrey Lazarus Associate Research Professor y codirector del Programa de Infecciones Víricas y Bacterianas
ISGlobal Team
- Camila Picchio Predoctoral Fellow
- Marcela Villota Research Assistant
Otros proyectos
Ver proyectos pasadosHep C Free Baleares
Eliminating hepatitis C on the Balearic Islands (Mallorca, Menorca and Ibiza): a study in governmental and non-governmental addiction service centres, a mobile methadone unit and a prison to test and link people who use drugs to HCV care.
COMBACTE
Combatiendo la Resistencia Bacteriana en Europa
Evaluación de estrategias para la erradicación de la enfermedad del Pian
Erradicación del Pian
Novel Marine Biomolecules against Biofilm (NoMorFilm)
Application to medical devices
COMBACTE-CARE
Combatting Bacterial Resistance in Europe - Carbapenem Resistance
Prioritising Antimicrobial Resistance: establishing an interdisciplinary International Research Partnership to tackle an evolving global health threat
An interdisciplinary International Research Partnership to tackle an evolving global health threat
Development of new metal-antibiotics against pathogens causing chronic infections in patients with cystic fibrosis.
New metal-antibiotics for patients with cystic fibrosis
HU-MEN (High frequency Ultrasound-based MENingitis screening)
Non-invasive ultrasound-based screening for meningitis: Proof-of concept in infants
Xpatial-TB
Improved case detection through TB contact risk stratification by Xpert results and spatial parameters in Mozambique
WHIP3TB
Evaluation of the effect of weekly high dose rifapentine and isoniazid (3HP) vs periodic 3HP vs 6H for preventing TB among HIV-positive individuals
New antibacterial agents against 'Acinetobacter baumannii'
Search for new target proteins and use of antibacterial or inhibitory peptides against resistance mechanisms in 'Acinetobacter baumannii'
Desarrollo de nuevos metaloantibióticos frente a patógenos causantes de infecciones crónicas en pacientes con fibrosis quística
VINCI
Optimizing provider-initiated HIV testing, linkage, and retention in care in the district of Manhiça, Mozambique
INTE-AFRICA
Integrating and decentralizing diabetes and hypertension services in Africa
AVATAR
Searching the hidden: evaluating dengue, chikungunya and Zika autochthonous transmission in the city of Barcelona.
COVID-PREG
Eficacia de hidroxicloroquina en la prevención de la infección por SARS-CoV-2 y de la gravedad de la enfermedad de COVID-19 durante el embarazo
SARS-CoV-2 Ivermectin Navarra-ISGlobal Trial (SAINT)
Estudio piloto para evaluar el potencial de la ivermectina para reducir la transmisión de COVID-19
Encuesta serológica Cendea de Cizur
Cendea de Cizur
CoViproteHCt
Projecte de Recerca en Resposta Immunitària i Epidemiologia de Malalties Infeccioses
Conèixer la propagació. Entendre la protecció
AMR DetecTool
A breakthrough device for the rapid detection of antimicrobial resistance
ANTICOV
Large Clinical Trial in Africa on the Treatment of Mild Cases of COVID-19
Stool4TB
Evaluating a new stool based qPCR for diagnosis of tuberculosis in children and people living with HIV
CAPTB
Close the Gap, Increase Access, Provide Adequate Therapy
SAFE (Superbug Awareness For Education)
Second Edition
STREESCO
Strengthening Epidemiological Surveillance in Benin and Burkina Faso for an Effective Response to COVID-19
COVAIR-CAT
Air Pollution in Relation to COVID-19 Morbidity and Mortality: A Large Population-Based Cohort Study in Catalonia
TB-RECONNECT
Reconnecting Transmission to Global Tuberculosis Control by Mapping Pathogen Transmission Events to Host Infection Status
SToolNIH
Quantifiable stool-based TB PCR to Improve Diagnostics and Treatment Monitoring
ALIA
Las ciudades y la salud
END-VOC
ENDing COVID-19 Variants Of concern through Cohort studies (END-VOC)
Estudio de la propagación de bacterias y genes de resistencia a los antibióticos en el ciclo integral del agua, en el área metropolitana de Barcelona
Propagación de la resistencia en aguas
Nuevos complejos de oro (III) frente a bacterias multirresistentes
Project Code: DTS21/00004
Desarrollo de dos nuevas estrategias terapéuticas (inhibidores de bombas de expulsion y ARN antisentido) activos frente a bacterias mutliresistentes
Más allá de la supresión vírica del VIH: un cuarto noventa para mejorar la salud de personas viviendo con el VIH en España
Project Code: PI20/01654
VH-COMSAVAC
Viral Hepatitis COMmunity Screening, Vaccination, and Care
TrackU
Una herramienta para conocer tu riesgo de contagio de SARS-CoV-2
ENDÈMIC
Community knowledge generation through scientific culture, urban ecology and art