Research

TB-RECONNECT

Reconnecting Transmission to Global Tuberculosis Control by Mapping Pathogen Transmission Events to Host Infection Status

Duration: 01/07/2021 - 30/06/2025
Coordinator: Iñaki Comas Espadas
Funded by: European Research Council (ERC)

The aim of the TB- RECONNECT is to shed light burning questions about the nature of tuberculosis (TB) transmission and the host and pathogen biology behind it, by synergizing three recent TB research developments:

1) The use of host blood transcriptomics to discriminate between infection status within the latent pool of individuals.
2) Quantification of transmission at a resolution not previously available, using pathogen genome sequencing.
3) The application of phylogenetic and epidemiological models to identify when transmission has happened.

Combining these three key developments with TB cohorts from multiple settings, and available tools from bacterial population genetics, high-throughput functional genomics and infection biology, we will be in a key position to reconnect transmission to TB control and inform major shifts in global and local control strategies.

Total Funding

530,000 €

ISGlobal Team

Patricia Comella Research Technician
Alberto García Basteiro
Belén Saavedra Predoctoral Fellow

Other projects

See Past Projects

COMBACTE

Combating Bacterial Resistance In Europe

Evaluation of Strategies for Yaws Eradication

Yaws eradication

Novel Marine Biomolecules against Biofilm (NoMorFilm)

Application to medical devices

COMBACTE-CARE

Combatting Bacterial Resistance in Europe - Carbapenem Resistance

Prioritising Antimicrobial Resistance: establishing an interdisciplinary International Research Partnership to tackle an evolving global health threat

An interdisciplinary International Research Partnership to tackle an evolving global health threat

Development of new metal-antibiotics against pathogens causing chronic infections in patients with cystic fibrosis.

New metal-antibiotics for patients with cystic fibrosis

HU-MEN (High frequency Ultrasound-based MENingitis screening)

Non-invasive ultrasound-based screening for meningitis: Proof-of concept in infants

Xpatial-TB

Improved case detection through TB contact risk stratification by Xpert results and spatial parameters in Mozambique

WHIP3TB

Evaluation of the effect of weekly high dose rifapentine and isoniazid (3HP) vs periodic 3HP vs 6H for preventing TB among HIV-positive individuals

New antibacterial agents against 'Acinetobacter baumannii'

Search for new target proteins and use of antibacterial or inhibitory peptides against resistance mechanisms in 'Acinetobacter baumannii'

Development of New Metalloantibiotics Against Pathogens Associated to Chronic Infections in Cystic Fibrosis Patients

VINCI

Optimizing provider-initiated HIV testing, linkage, and retention in care in the district of Manhiça, Mozambique

INTE-AFRICA

Integrating and decentralizing diabetes and hypertension services in Africa

AVATAR

Searching the hidden: evaluating dengue, chikungunya and Zika autochthonous transmission in the city of Barcelona.

COVID-PREG

Eficacia de hidroxicloroquina en la prevención de la infección por SARS-CoV-2 y de la gravedad de la enfermedad de COVID-19 durante el embarazo

SARS-CoV-2 Ivermectin Navarra-ISGlobal Trial (SAINT)

Pilot Study to Evaluate the Potential of Ivermectin to Reduce COVID-19 Transmission

Encuesta serológica Cendea de Cizur

Cendea de Cizur

CoViproteHCt

Projecte de Recerca en Resposta Immunitària i Epidemiologia de Malalties Infeccioses

Conèixer la propagació. Entendre la protecció

AMR DetecTool

A breakthrough device for the rapid detection of antimicrobial resistance

ANTICOV

Large Clinical Trial in Africa on the Treatment of Mild Cases of COVID-19

HBV-COMSAVA

Hepatitis B Virus COMmunity Screening and Vaccination in Africans

Stool4TB

Evaluating a new stool based qPCR for diagnosis of tuberculosis in children and people living with HIV

Hep C Free Baleares

Eliminating hepatitis C on the Balearic Islands (Mallorca, Menorca and Ibiza): a study in governmental and non-governmental addiction service centres, a mobile methadone unit and a prison to test and link people who use drugs to HCV care.

CAPTB

Close the Gap, Increase Access, Provide Adequate Therapy

SAFE (Superbug Awareness For Education)

Second Edition

STREESCO

Strengthening Epidemiological Surveillance in Benin and Burkina Faso for an Effective Response to COVID-19

COVAIR-CAT

Air Pollution in Relation to COVID-19 Morbidity and Mortality: A Large Population-Based Cohort Study in Catalonia

SToolNIH

Quantifiable stool-based TB PCR to Improve Diagnostics and Treatment Monitoring

ALIA

Las ciudades y la salud

END-VOC

ENDing COVID-19 Variants Of concern through Cohort studies (END-VOC)

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Duration

Aim

COOKIE_SUPPORT

First Party

50 years

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First Party

50 years

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First Party

Session

Liferay uses these cookies to manage your access ID

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Liferay uses these cookies to manage your access ID

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First Party

5 years

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First Party

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Google

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Google

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Google

6 months

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Google

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Google

2 years

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Google

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Used by Google to store user preferences and information of Google

SIDCC

Google

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Used by Google to store user preferences and information of Google

SSID

Google

2 years

Used by Google to store user preferences and information of Google

__Secure-3PAPISID

Google

2 years

Used by for targeting purposes to build a profile of the website visitor's interests in order to show relevant & personalised Google advertising

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Google

2 years

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Google

2 years

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CONSENT

Google

20 years

Used by Google to store user preferences and information of Google

vuid

Vimeo

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APISID

YouTube

2 years

These cookies are set via embedded YouTube videos. They register anonymous statistical data

HSID

YouTube

2 years

These cookies are set via embedded YouTube videos. They register anonymous statistical data

LOGIN_INFO

YouTube

2 years

These cookies are set via embedded YouTube videos. They register anonymous statistical data

PREF

YouTube

2 years

Cookie that remembers information that changes the appearance or behaviour of the web site, such as the user's preferred language or region.

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YouTube

2 years

These cookies are set via embedded YouTube videos. They register anonymous statistical data

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YouTube

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These cookies are set via embedded YouTube videos. They register anonymous statistical data

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YouTube

1 year

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YouTube

2 years

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YouTube

1 year

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YSC

YouTube

Session

This cookie is set by the YouTube video service on pages with embedded YouTube video

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YouTube

20 years

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__Secure-3PAPISID

YouTube

2 years

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__Secure-3PSID

YouTube

2 years

Used by for targeting purposes to build a profile of the website visitor's interests in order to show relevant & personalised Google advertising

__Secure-3PSIDCC

YouTube

2 years

Used by for targeting purposes to build a profile of the website visitor's interests in order to show relevant & personalised Google advertising

iutk

issuu

10 years

Recognises the user's device and what Issuu documents have been read.

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infogram

Session

Tells Infogram which site is embedding the content

ig_putma

infogram

Session

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Google Analytics

24 hours

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Duration

Aim

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Google

3 months

Used by Google for experimenting with advertisement efficiency

IDE

Google (doubleclick)

13 months

Used by Google to show relevant advertising to the viewer across the web

datr

Facebook

2 years

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10 years

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YouTube

Session

These cookies are set via embedded YouTube videos. They register anonymous statistical data

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YouTube

Session

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TB-RECONNECT

Total Funding

ISGlobal Team

Other projects

COMBACTE

Evaluation of Strategies for Yaws Eradication

Novel Marine Biomolecules against Biofilm (NoMorFilm)

COMBACTE-CARE

Prioritising Antimicrobial Resistance: establishing an interdisciplinary International Research Partnership to tackle an evolving global health threat

Development of new metal-antibiotics against pathogens causing chronic infections in patients with cystic fibrosis.

HU-MEN (High frequency Ultrasound-based MENingitis screening)

Xpatial-TB

WHIP3TB

New antibacterial agents against 'Acinetobacter baumannii'

Development of New Metalloantibiotics Against Pathogens Associated to Chronic Infections in Cystic Fibrosis Patients

VINCI

INTE-AFRICA

AVATAR

COVID-PREG

SARS-CoV-2 Ivermectin Navarra-ISGlobal Trial (SAINT)

Encuesta serológica Cendea de Cizur

CoViproteHCt

Projecte de Recerca en Resposta Immunitària i Epidemiologia de Malalties Infeccioses

AMR DetecTool

ANTICOV

HBV-COMSAVA

Stool4TB

Hep C Free Baleares

CAPTB

SAFE (Superbug Awareness For Education)

STREESCO

COVAIR-CAT

SToolNIH

ALIA

END-VOC

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Total Funding

Our Team

ISGlobal Team

Other projects