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Luis Molinos

Luis Molinos

Junior Research Leader Malària i malalties parasitàries desateses | Malària i malalties parasitàries desateses

Luis M Molinos-Albert is a B-cell immunologist with an expertise on molecular aspects of the antibody response to pathogens, primarily HIV-1, SARS-CoV-2, malaria and hepatitis viruses. Over the last ten years, he has been working on human B-cell antibody responses, exploring the B-cell dynamics in health and disease to understand how protective antibodies are generated. He is currently a Senior Postdoctoral Researcher in the Malaria Immunology group, where he is applying his expertise into the molecular characterization of the memory B-cell antibody response to the RTS,S malaria vaccine in African children recipients. To this aim he has established and optimized the tools for antigen-specific B-cell isolation and molecular cloning of monoclonal antibodies. He also coordinates longitudinal studies focused on the memory B-cell antibody response to SARS-CoV-2  in large cohorts of healthcare workers. Finally, he set up and currently coordinates a full pipeline for recombinant protein production in eukaryotic cell lines, which provides antigenic supply to the different studies of the group as well as to the Core Facility on Immune Response and Biomarkers.

Publicacions principals

  • Torres C, Jiménez A, Deulofeu M, Prenafeta A, Dobaño C, Moncunill G, Ferrer L, Molinos-Albert LM. Antibody and B-Cell Responses to PHH-1V81 XBB.1.16- Adapted SARS-CoV-2 Booster Vaccination Are Associated with Variant Neutralization. J Med Virol. 2025 Sep;97(9):e70583. 
  • Molinos-Albert LM, Baquero E, Planchais C, Doceul V, El Costa H, Mottez E, Mallet V, Pol S, Albert ML, Pavio N, Alanio C, Dimitrov JD, Mouquet H. Structural basis for hepatitis E virus neutralization by potent human antibodies. Sci Adv. 2025 May 9;11(19):eadu8811.
  • Macià D, Campo JJ, Jairoce C, Mpina M, Sorgho H, Dosoo D, Agnandji ST, Kusi KA, Molinos-Albert LM, Kariuki S, Daubenberger C, Mordmüller B, Moncunill G, Dobaño C. The effect of Plasmodium falciparum exposure and maternal anticircumsporozoite protein antibodies on responses to RTS,S/AS01(E) vaccination in infants and children: an ancillary observational immunological study to a phase 3, randomised clinical trial. Lancet Infect Dis. 2025 Mar;25(3):335-345. 
  • Molinos-Albert LM*, Rubio R, Martín-Pérez C, Pradenas E, Torres C, Jiménez A, Canyelles M, Vidal M, Barrios D, Marfil S, Aparicio E, Ramírez-Morros A, Trinité B, Vidal-Alaball J, Santamaria P, Serra P, Izquierdo L, Aguilar R, Ruiz- Comellas A, Blanco J, Dobaño C, Moncunill G. Long-lasting antibody B-cell responses to SARS-CoV-2 three years after the onset of the pandemic. Cell Rep. 2025 Apr 22;44(4):115498.
  • Molinos-Albert LM, Baquero E, Bouvin-Pley M, Lorin V, Charre C, Planchais C, Dimitrov JD, Monceaux V, Vos M, Hocqueloux L, Berger JL, Seaman MS, Braibant M, Avettand-Fenoël V, Sáez-Cirión A, Mouquet H. Anti-V1/V3-glycan broadly HIV-1 neutralizing antibodies in a post-treatment controller. Cell Host Microbe. 2023 Aug 9;31(8):1275-1287.e8. 
  • Molinos-Albert LM, Baquero E, Bouvin-Pley M, Lorin V, Charre C, Planchais C, Dimitrov JD, Monceaux V, Vos M, Hocqueloux L, Berger JL, Seaman MS, Braibant M, Avettand-Fenoël V, Sáez-Cirión A, Mouquet H. Anti-V1/V3-glycan broadly HIV-1 neutralizing antibodies in a post-treatment controller. Cell Host Microbe. 2023 Aug 9;31(8):1275-1287.e8.
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