Alfredo Mayor uses a discovery-oriented approach guided by priorities identified by malaria endemic countries and grounded in collaborative efforts to provide scientific evidence on the value of innovative approaches for malaria surveillance and action, with a special emphasis in Mozambique.
His research activities rely on four key principles:
- Advancing scientific knowledge on malaria to improve malaria control and elimination
- Prioritization based on programmatic needs though a dialogue with National Malaria Control Program (NMCP) and other stakeholders
- Translational approach building from basic biology of host-parasite interactions
- Empowering the new generation of researchers in Mozambique and other malaria endemic countries through capacity building and rooting research in the country.
The public health impact that Mayor is pursuing with his research is:
- Guide interventions at scale through a cost-effective and granular malaria stratification
- Select impactful interventions through an improved understanding of their efficacy and effectiveness in reducing transmission
- Early warning of parasite threats that can compromise control and elimination
- Target the transmission reservoir for malaria elimination by triggering locally targeted responses
- Expand national capacities to transform surveillance into a key malaria intervention
- Reduce malaria morbidity and mortality.
To conduct the research activities, Mayor has combined omic tools (next generation sequencing, high-throughput serological assays and transcriptomics), state-of the art epidemiological approaches (impact evaluations, analysis of geo-spatial clustering and modelling) and clinical trials to inform the Ministries of Health on tools for malaria control and elimination.
- King M, George AE, Cisteró P, Tarr Attia CK, Arregui B, Omeonga S, Chen H, García Sípido AM, Sarukhan A, Bassat Q, Lansana DP, Mayor A. No evidence of false-negative Plasmodium falciparum rapid diagnostic results in Monrovia, Liberia. Malar J (2021) 20:238
- Gupta H, Rubio M, Sitoe A, Varo R, Cisteró P, Madrid L, Cuamba I, Jimenez A, Martiáñez-Vendrell X, Barrios D, Pantano L, Brimacombe A, Bustamante M, Bassat Q, Mayor A. Plasma microRNA profiling for malaria disease: association with severity and P. falciparum biomass. Emerg Infect Dis. 2021 Feb;27(2):430-442.
- Huijben S, Macete E, Mombo-Ngoma G, Ramharter M, Kariuki S, Desai M, Shi YP, Mwangoka G, Massougbodji A, Cot M, Ndam NT, Uberegui E, Gupta H, Cisteró P, Aponte JJ, González R, Menéndez C, Mayor A. Counter-Selection of Antimalarial Resistance Polymorphisms by Intermittent Preventive Treatment in Pregnancy. J Infect Dis. 2020 Jan 2;221(2):293-303.
- Fonseca AM, González R, Bardají A, Jairoce C, Rupérez M, Jiménez A, Quintó L, Cisteró P, Vala A, Sacoor C, Gupta H, Hegewisch-Taylor J, Brew J, Ndam NT, Kariuki S, López M, Dobaño C, Chitnis CE, Ouma P, Ramharter M, Abdulla S, Aponte JJ, Massougbodji A, Briand V, Mombo-Ngoma G, Desai M, Cot M, Nhacolo A, Sevene E, Macete E, Menéndez C, Mayor A. VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy. Emerg Infect Dis. 2019 Oct;25(10):1851-1860.
- Mayor A, Menéndez C, Walker PGT. Targeting Pregnant Women for Malaria Surveillance. Trends Parasitol. 2019 Sep;35(9):677-686.
- Mayor A, Martínez-Pérez G, Tarr-Attia CK, Breeze-Barry B, Sarukhan A, García-Sípido AM, Hurtado JC, Lansana DP, Casamitjana N. Training through malaria research: building capacity in good clinical and laboratory practice in Liberia. Malar J. 2019 Apr 17;18(1):136.
- Galatas, B., Martí-Soler H, Nhamussua L, Cisteró P, Aide P, Saute F, Menéndez C, Rabinovich R, Alonso PL, Bassat Q, Mayor, A. Dynamics of afebrile Plasmodium falciparum Infections in Mozambican Men. Clin Infect Dis. 2018 Sep 14;67(7):1045-1052.
- Ndam NT, Mbuba E, González R, Cisteró P, Kariuki S, Sevene E, Rupérez M, Fonseca AM, Vala A, Maculuve S, Jiménez A, Quintó L, Ouma P, Ramharter M, Aponte JJ, Nhacolo A, Massougbodji A, Briand V, Kremsner PG, Mombo-Ngoma G, Desai M, Macete E, Cot M, Menéndez C, Mayor A. Resisting and tolerating P. falciparum in pregnancy under different malaria transmission intensities. BMC Med. 2017 Jul 17;15(1):130.
- Galatas B, Bassat Q, Mayor A. Malaria Parasites in the Asymptomatic: Looking for the Hay in the Haystack. Trends Parasitol. 2016 Apr;32(4):296-308.
- Mayor A, Bardají, A, Macete E, Nhampossa T, Fonseca AM, González, R, Maculuve S, Cisteró P, Rupérez, M, Campo J, Vala A, Sigaúque B, Jimenez A, Machevo S, de la Fuente L, Nhama A, Luis L, Aponte JJ, Acácio S, Nhacolo A, Chitnis C, Dobaño C, Sevene E, Alonso PL, Menéndez C. Changing Trends in P. falciparum Burden, Immunity, and Disease in Pregnancy. N Engl J Med. 2015 Oct 22;373(17):1607-17.