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PLASTICINE

Microplastics exposure in infants and adults, and the association with intestinal markers of inflammation, permeability, and microbiota

Durada
01/01/2024 - 31/12/2026
Coordinador
Cristina Villanueva
Finançadors
Proyecto PI23/00615

Los microplásticos son contaminantes emergentes presentes en alimentos, el agua de consumo y la atmósfera. Se desconoce la exposición en la población y los posibles efectos en la salud. 

El objetivo del proyecto PLASTICINE es evaluar la exposición a microplásticos y la asociación con marcadores de salud intestinal en población general en diferentes momentos de la vida. Los objetivos específicos son:

  • Medir la concentración de microplásticos en muestras biológicas (heces)
  • Identificar variables personales que determinan las concentraciones
  • Evaluar la asociación con marcadores de salud intestinal (microbioma, inflamación, e integridad de la mucosa). 

Métodos

La población de estudio incluye bebés de 18 meses de edad participantes en la cohorte BiSC (N=400), y adultos sanos participantes en un estudio previo (N=50), ambos en Barcelona y área metropolitana. A través de cuestionarios se ha recogido información sobre alimentación, factores socio-demográficos, estilo de vida, etc. Se disponen de muestras de heces recogidas previamente (2022-2023) siguiendo protocolos específicos para los marcadores a analizar y congelados (-20/-80º). 

Se analizarán microplásticos en muestras de bebés y marcadores de salud intestinal en muestras de adultos: microbioma, calprotectina y zonulina (ELISA). Se dispone de medidas de microbiota en las mismas muestras de bebés, y microplásticos en las mismas muestras de adultos. El análisis de datos incluirá una descriptiva de todas las variables y modelos multivariados para cuantificar la asociación entre marcadores de salud intestinal y concentración de microplásticos ajustando por covariables. 

Financiación 

158.750 €

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