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ALTER

Air Pollution, Gut Microbiota and Neurodevelopment in the First 24 Months of Life

Projecte ALTER
Foto: Micael Widell / Pexels
Durada
01/01/2022 - 31/12/2024
Coordinador
Mireia Gascon
Finançadors
Instituto de Salud Carlos III (ISCIII)

The biological mechanisms by which early exposure to air pollution is associated with children's health effects, specifically neurodevelopment, is a significant knowledge gap, and more research is needed. Our hypothesis is that exposure to air pollution during pre- and postnatal life induces gut microbiota dysbiosis (i.e. alterations in gut microbiota composition and biological activity), which partially explains the association between air pollution exposure and subclinical neurodevelopment delays in the first years of life.

Objective

The main objective of the ALTER project is to longitudinally assess the impact that pre and post-natal exposure to air pollution has on the gut microbiota composition and its biological activity in the first two years of life.

We also aim to explore whether gut microbiota dysbiosis mediates the association between air pollution exposure and neurodevelopment outcomes.

The study will be conducted in a general population birth cohort (n=600) with a detailed assessment of prenatal and postnatal air pollution at personal and home levels. Gut microbiota composition (rRNA 16s) and its biological activity (with the assessment of short chain fatty acids - SCFAs) will be assessed at the age of 6 and 18 months, while neurodevelopment will be assessed between the 6th and 24th month of life (using international validated tests).

Assessing the impact of air pollutants on subclinical events (i.e. gut microbiota alterations) is innovative and will allow advancing knowledge on the potential mechanisms by which air pollution affects neurodevelopment in early life.

Total Funding

147.620 €

Our Team

Project Coordinator

ISGlobal Team

External Team

  • Carla Domínguez
    Carla Domínguez
  • Elisabeth Suades
    Elisabeth Suades

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