Publicador de contenidos

INMA Cardio

Exposiciones ambientales a edad temprana y riesgo cardiovascular del adolescente

Duración
2016 - 2019
Coordinador
Martine Vrijheid (ISGlobal)
Financiadores
Ministerio de Ciencia, Innovación y Universidades, Instituto de Salud Carlos III, Unión Europea. Este proyecto está cofinanciado por el Fondo Europeo de Desarrollo Regional (FEDER). “Una manera de hacer Europa”

There is a growing body of evidence demonstrating that developmental adaptations in response to adverse environmental risk factors early in life may permanently affect the structure and function of cardiovascular and metabolic systems, leading to common health problems such as obesity, diabetes, and cardiovascular diseases.

INMA-Cardio aims to examine whether fetal and infant life-style, social and environmental exposures influence cardiovascular risk profiles in early adolescence in the longitudinal birth cohort study INMA, using novel phenotypes and novel multiple exposure analysis approaches.

INMA-Cardio will start a new follow-up examination of the INMA children at 12 years of age (all 550 children still in the study). As part of INMA-Cardio we will measure cardiovascular and metabolic outcomes (pulse wave velocity, retinal vessel diameters, heart rate variability, blood pressure, and markers of besity/adiposity) in the children, we will analyse mechanistic biomarkers of metabolic function, inflammation and oxidative stress, and we will conduct questionnaires and a basic cardiometabolic examination with their mothers. Further, we will make advantage of all previously collected data on environmental (chemical and air contaminants), social and life style factors and use new multifactorial analysis approaches. INMA-Cardio is novel in that it will be the first and largest longitudinal study to combine cardiovascular risk profiles and measurements of multiple exposures and risk factors during sensitive developmental time periods and integrate mechanistic biomarkers. This will gain new insights in the environmental origins of cardiovascular disease risk.

Total Funding

104.665 euros

Project Code

PI15/00118

 

Nuestro equipo

Principal Investigator (PI)

  • Martine Vrijheid
    Martine Vrijheid Research Professor y directora del Programa de Medio ambiente y salud a lo largo de la vida

Otros proyectos

Ver proyectos pasados

MCC-Spain

Estudio multi-caso control poblacional, incluyendo tumores de alta incidencia en España

HELIX

Novel tools for integrating early-life environmental exposures and child health across Europe

EGG/EAGLE

Early Genetics Growth/Early Genetics and Lifecourse Epidemiology

PACE

Pregnancy and Childhood Epigenetics

LIFECYCLE

Early-life stressors and LifeCycle health

OMEGA-NET

Network on the Coordination and Harmonisation of European Occupational Cohorts

HARMONIC

Health effects of cArdiac fluoRoscopy and mOdern radIotherapy in paediatriCs

Mobilise-D

Connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement

EARLY-ADAPT

Signs of Early Adaptation to Climate Change

COVICAT

Cohorte Covid-19 en Cataluña

ATHLETE

Advancing Tools for Human Early Lifecourse Exposome Research and Translation

CONTENT

Cohorte de COVID-19 en España: dinámica social, salud mental y desigualdades

EUCAN-Connect

A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health

OBERON

An integrative strategy of testing systems for identification of EDs related to metabolic disorders

EXPANSE

EXposome Powered tools for healthy living in urbAN SEttings

AURORA 2021

Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics

ONES

Fine Particle Matter, Fetal Growth, and Neurodevelopment: Examining Critical Windows of Susceptibility

AIR-NB

Pre-natal exposure to urban AIR pollution and pre- and post-Natal Brain development

NutinBrain

The role of seafood and nut consumption on human neurodevelopment from pregnancy to adolescence

UrbanKids

Urban and social environment and childhood obesity – a natural moving2health experiment

iGenCO

In-Depth Genomics and Cross-Omics Analysis for Undiagnosed Rare Diseases on a User-Friendly Collaborative Platform

CityExposomeCat

An Exposome Approach to Urban Health: Individualized Environmental Exposure Assessment in an Adults Population Cohort Study (GCAT)

TwinAir

Digital Twins Enabled Indoor Air Quality Management for Healthy Living

UBDPOLICY

The Urban Burden of Disease Estimation for POLICY Making

TOLIFE

Combining Artificial Intelligence and smart sensing TOward better management and improved quality of LIFE in chronic obstructive pulmonary disease

BWater

Drinking Water in Barcelona: Sustainability and Health Impact Assessment

intoDBP

Innovative Tools to Control Organic Matter and Disinfection Byproducts in Drinking Water

FINDOOR

FTIR spectroscopy for real-time detection of bacterial outbreaks and the rapid identification of pathogenic serotypes, relapsing infections and antibiotic resistance

OccRF-Health

Occupational exposure to radiofrequency electromagnetic fields: From exposure assessment to study of health in workers and their offspring

EPHOR

Exposome Project for Health and Occupational Research

EXPONIT

Analysing and studying how night shift work affects workers' circadian rhythms and health

IHEN

International Human Exposome Network

B-Triage

Una prueba en el punto de atención para la estratificación del riesgo de los pacientes febriles basada en los niveles de sTREM-1

e-QuoL

e-health tools to promote Equality in Quality of Life for childhood to young adulthood cancer patients, survivors and their families