INMA Cardio

Exposiciones ambientales a edad temprana y riesgo cardiovascular del adolescente

2016 - 2019
Martine Vrijheid (ISGlobal)
Ministerio de Ciencia, Innovación y Universidades, Instituto de Salud Carlos III, Unión Europea. Este proyecto está cofinanciado por el Fondo Europeo de Desarrollo Regional (FEDER). “Una manera de hacer Europa”

There is a growing body of evidence demonstrating that developmental adaptations in response to adverse environmental risk factors early in life may permanently affect the structure and function of cardiovascular and metabolic systems, leading to common health problems such as obesity, diabetes, and cardiovascular diseases.

INMA-Cardio aims to examine whether fetal and infant life-style, social and environmental exposures influence cardiovascular risk profiles in early adolescence in the longitudinal birth cohort study INMA, using novel phenotypes and novel multiple exposure analysis approaches.

INMA-Cardio will start a new follow-up examination of the INMA children at 12 years of age (all 550 children still in the study). As part of INMA-Cardio we will measure cardiovascular and metabolic outcomes (pulse wave velocity, retinal vessel diameters, heart rate variability, blood pressure, and markers of besity/adiposity) in the children, we will analyse mechanistic biomarkers of metabolic function, inflammation and oxidative stress, and we will conduct questionnaires and a basic cardiometabolic examination with their mothers. Further, we will make advantage of all previously collected data on environmental (chemical and air contaminants), social and life style factors and use new multifactorial analysis approaches. INMA-Cardio is novel in that it will be the first and largest longitudinal study to combine cardiovascular risk profiles and measurements of multiple exposures and risk factors during sensitive developmental time periods and integrate mechanistic biomarkers. This will gain new insights in the environmental origins of cardiovascular disease risk.

Total Funding

104.665 euros

Project Code



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