The META Trial

Preventing and delaying the development of diabetes in Africa: A randomised placebo-controlled double-blind Phase III trial of metformin in HIV-infected persons with pre-diabetes

Duration: 17/01/2025 - 31/12/2026
Coordinator: ISGlobal and University College London (UCL)
Funded by: European Union
Website: https://www.inteafrica.org/related-projects/meta-trial/

The META Trial is the largest trial of metformin conducted in Africa. It is aimed at identifying a low-cost intervention to prevent or delay onset of diabetes in individuals living with HIV and pre-diabetes, who are on antiretroviral therapy (ART) in the continent.

Not only will it produce globally relevant evidence on this question, but in ancillary studies, we will compare diagnostic methods for diabetes and use various clinical data to describe diabetes and HIV-related complications in this population. Developing clinical skills and capacity for conduct of clinical trials is central to the capacity development aims of the META Trial.

Total Funding

1.800.000€

Equipo ISGlobal

Anthony Armenta Jr Health Communications Officer
Jeffrey Lazarus Head of the Public Health Liver Group
Delfina Boudou Global Health Project Manager

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ENDÈMIC

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The META Trial