Research, Antimicrobial Resistance

Desarrollo de dos nuevas estrategias terapéuticas (inhibidores de bombas de expulsion y ARN antisentido) activos frente a bacterias mutliresistentes

Duration: 01/01/2021 - 31/ 12/ 2023
Coordinator: Jordi Vila
Funded by: Instituto de Salud Carlos III Unión Europea Este proyecto está cofinanciado por el Fondo Europeo de Desarrollo Regional (FEDER). “Una manera de hacer Europa”

En la actualidad una gran parte de los antibióticos disponibles no son aptos para el tratamiento de los patógenos multirresistentes. En ocasiones las posibilidades de elección se reducen a un solo fármaco, como es el caso de colistina para A. baumannii, además los nuevos antibióticos no son activos frente a este microorganismo. En un documento reciente la OMS posiciona a A. baumannii, P. aeruginosa y Klebsiella pneumoniae productora de BLEES y/o carbapenemasas en el primer lugar en el conjunto de microorganismos multirresistentes frente a los que es necesario una mayor investigación para el diseño de antibacterianos.

El principal objetivo de este proyecto es el diseño de nuevos agentes antibacterianos frente a estos microorganismos mediante dos abordajes distintos:

Estudio de la capacidad del bloqueo de sistemas de expulsión activa mediante péptidos cíclicos que bloqueen la salida del antibiótico a través del poro constituido por la porina de expulsión
Disponemos de un híbrido péptido conjugado con un ARN antisentido y en este proyecto se investigará su capacidad letal tanto “in vitro” como “in vivo” para inhibir la expresión de genes esenciales para la viabilidad de los microorganismos anteriormente citados. Además, se diseñarán y evaluarán otros ARN antisentido.

Financiación total:

82.000€

Coordinator

Jordi Vila Research Professor, Director of the Antimicrobial Resistance Initiative and Co-Director of the Viral and Bacterial Infections Programme

Other projects

See Past Projects

COMBACTE

Combating Bacterial Resistance In Europe

Evaluation of Strategies for Yaws Eradication

Yaws eradication

Novel Marine Biomolecules against Biofilm (NoMorFilm)

Application to medical devices

COMBACTE-CARE

Combatting Bacterial Resistance in Europe - Carbapenem Resistance

Prioritising Antimicrobial Resistance: establishing an interdisciplinary International Research Partnership to tackle an evolving global health threat

An interdisciplinary International Research Partnership to tackle an evolving global health threat

Development of new metal-antibiotics against pathogens causing chronic infections in patients with cystic fibrosis.

New metal-antibiotics for patients with cystic fibrosis

HU-MEN (High frequency Ultrasound-based MENingitis screening)

Non-invasive ultrasound-based screening for meningitis: Proof-of concept in infants

Xpatial-TB

Improved case detection through TB contact risk stratification by Xpert results and spatial parameters in Mozambique

WHIP3TB

Evaluation of the effect of weekly high dose rifapentine and isoniazid (3HP) vs periodic 3HP vs 6H for preventing TB among HIV-positive individuals

New antibacterial agents against 'Acinetobacter baumannii'

Search for new target proteins and use of antibacterial or inhibitory peptides against resistance mechanisms in 'Acinetobacter baumannii'

Development of New Metalloantibiotics Against Pathogens Associated to Chronic Infections in Cystic Fibrosis Patients

VINCI

Optimizing provider-initiated HIV testing, linkage, and retention in care in the district of Manhiça, Mozambique

INTE-AFRICA

Integrating and decentralizing diabetes and hypertension services in Africa

AVATAR

Searching the hidden: evaluating dengue, chikungunya and Zika autochthonous transmission in the city of Barcelona.

COVID-PREG

Eficacia de hidroxicloroquina en la prevención de la infección por SARS-CoV-2 y de la gravedad de la enfermedad de COVID-19 durante el embarazo

SARS-CoV-2 Ivermectin Navarra-ISGlobal Trial (SAINT)

Pilot Study to Evaluate the Potential of Ivermectin to Reduce COVID-19 Transmission

Encuesta serológica Cendea de Cizur

Cendea de Cizur

CoViproteHCt

Projecte de Recerca en Resposta Immunitària i Epidemiologia de Malalties Infeccioses

Conèixer la propagació. Entendre la protecció

AMR DetecTool

A breakthrough device for the rapid detection of antimicrobial resistance

ANTICOV

Large Clinical Trial in Africa on the Treatment of Mild Cases of COVID-19

HBV-COMSAVA

Hepatitis B Virus COMmunity Screening and Vaccination in Africans

Stool4TB

Evaluating a new stool based qPCR for diagnosis of tuberculosis in children and people living with HIV

Hep C Free Baleares

Eliminating hepatitis C on the Balearic Islands (Mallorca, Menorca and Ibiza): a study in governmental and non-governmental addiction service centres, a mobile methadone unit and a prison to test and link people who use drugs to HCV care.

CAPTB

Close the Gap, Increase Access, Provide Adequate Therapy

SAFE (Superbug Awareness For Education)

Second Edition

STREESCO

Strengthening Epidemiological Surveillance in Benin and Burkina Faso for an Effective Response to COVID-19

COVAIR-CAT

Air Pollution in Relation to COVID-19 Morbidity and Mortality: A Large Population-Based Cohort Study in Catalonia

TB-RECONNECT

Reconnecting Transmission to Global Tuberculosis Control by Mapping Pathogen Transmission Events to Host Infection Status

SToolNIH

Quantifiable stool-based TB PCR to Improve Diagnostics and Treatment Monitoring

ALIA

Las ciudades y la salud

END-VOC

ENDing COVID-19 Variants Of concern through Cohort studies (END-VOC)

Estudio de la propagación de bacterias y genes de resistencia a los antibióticos en el ciclo integral del agua, en el área metropolitana de Barcelona

Propagación de la resistencia en aguas

Nuevos complejos de oro (III) frente a bacterias multirresistentes

Project Code: DTS21/00004

Más allá de la supresión vírica del VIH: un cuarto noventa para mejorar la salud de personas viviendo con el VIH en España

Project Code: PI20/01654

VH-COMSAVAC

Viral Hepatitis COMmunity Screening, Vaccination, and Care

ENDÈMIC

Community knowledge generation through scientific culture, urban ecology and art

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Duration

Aim

COOKIE_SUPPORT

First Party

50 years

A cookie that checks whether cookies are enabled in your browser.

GUEST_LANGUAGE_ID

First Party

50 years

Cookie used to remember the user's language preferences.

JSESSIONID

First Party

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First Party

Session

Liferay uses these cookies to manage your access ID

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First Party

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Liferay uses these cookies to manage your access ID

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First Party

5 years

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First Party

Session

Liferay company identifier

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Liferay uses these cookies to manage your access ID

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First Party

14 days

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ck_newsletter

First Party

14 days

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Google

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Google

2 years

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Google

2 years

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Google

6 months

Advertising cookie used to tailor the advertisements shown to the interests of the user.

Google

Session

Used by Google to store user preferences and information of Google

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Google

2 years

Used by Google to store user preferences and information of Google

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Google

2 years

Used by Google to store user preferences and information of Google

SIDCC

Google

3 months

Used by Google to store user preferences and information of Google

SSID

Google

2 years

Used by Google to store user preferences and information of Google

__Secure-3PAPISID

Google

2 years

Used by for targeting purposes to build a profile of the website visitor's interests in order to show relevant & personalised Google advertising

__Secure-3PSID

Google

2 years

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Google

2 years

Used by for targeting purposes to build a profile of the website visitor's interests in order to show relevant & personalised Google advertising

CONSENT

Google

20 years

Used by Google to store user preferences and information of Google

vuid

Vimeo

2 years

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APISID

YouTube

2 years

These cookies are set via embedded YouTube videos. They register anonymous statistical data

HSID

YouTube

2 years

These cookies are set via embedded YouTube videos. They register anonymous statistical data

LOGIN_INFO

YouTube

2 years

These cookies are set via embedded YouTube videos. They register anonymous statistical data

PREF

YouTube

2 years

Cookie that remembers information that changes the appearance or behaviour of the web site, such as the user's preferred language or region.

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YouTube

2 years

These cookies are set via embedded YouTube videos. They register anonymous statistical data

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YouTube

2 years

These cookies are set via embedded YouTube videos. They register anonymous statistical data

SIDCC

YouTube

1 year

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YouTube

2 years

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YouTube

1 year

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YSC

YouTube

Session

This cookie is set by the YouTube video service on pages with embedded YouTube video

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YouTube

20 years

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YouTube

2 years

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YouTube

2 years

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YouTube

2 years

Used by for targeting purposes to build a profile of the website visitor's interests in order to show relevant & personalised Google advertising

iutk

issuu

10 years

Recognises the user's device and what Issuu documents have been read.

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infogram

Session

Tells Infogram which site is embedding the content

ig_putma

infogram

Session

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Cookie	Management	Duration	Aim
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Duration

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Google Analytics

2 years

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Google Analytics

1 minute

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Google Analytics

24 hours

Used to distinguish users

Cookie	Management	Duration	Aim
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s_gl	YouTube	Session

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Duration

Aim

_gcl_au

Google

3 months

Used by Google for experimenting with advertisement efficiency

IDE

Google (doubleclick)

13 months

Used by Google to show relevant advertising to the viewer across the web

datr

Facebook

2 years

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Facebook

2 years

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3 months

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10 years

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10 years

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10 years

wide

YouTube

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These cookies are set via embedded YouTube videos. They register anonymous statistical data

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YouTube

Session

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Financiación total:

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