Research Programmes
Research

CAPTB

Close the Gap, Increase Access, Provide Adequate Therapy

Healthcare Unit in a Mozambican hospital
Photo: Andalu Vila San Juan
Duration
01/09/2019 - 01/03/2023
Coordinator
Samuel Schumacher (Foundation for Innovative New Diagnostics, FIND, Switzerland)
Funded by
EDCTP
Website
https://www.tb-capt.org/

The proposed trials will demonstrate (i) the impact of Omni/Ultra and Omni/XDR at a microscopy-centre level on patient-important outcomes; (ii) the impact of Ultra testing of pulmonary and extra-pulmonary samples on mortality in patients with advanced HIV; (iii) the utility of process innovation and supportive solutions for diagnostics (e.g. connectivity) to improve linkage to care, surveillance, stock and device management; and (iv) the needs for staffing, training, stock management and maintenance for implementation of a molecular test at microscopy centre level. Furthermore, it will enable socio-economic and population level impact modelling.

The trial is designed to provide evidence for the most impactful implementation strategies depending on local epidemiology and existing infrastructure, rather than just providing evidence on technology introduction. As such, the work outlined in the proposal aims to support the policy-making mandate of WHO and participating ministries of health and implementation planning for scale-up. Further, the project will establish centres of excellence for the implementation of diagnostic trials that will serve in the evaluation of future tests.

Total Funding

5,975,984.15 €

Our Team

Project Coordinator

  • Samuel Schumacher (FIND, Switzerland)
    Samuel Schumacher (FIND, Switzerland)

ISGlobal Staff

Other projects

See Past Projects

COMBACTE

Combating Bacterial Resistance In Europe

COMBACTE-CARE

Combatting Bacterial Resistance in Europe - Carbapenem Resistance

Xpatial-TB

Improved case detection through TB contact risk stratification by Xpert results and spatial parameters in Mozambique

WHIP3TB

Evaluation of the effect of weekly high dose rifapentine and isoniazid (3HP) vs periodic 3HP vs 6H for preventing TB among HIV-positive individuals

VINCI

Optimizing provider-initiated HIV testing, linkage, and retention in care in the district of Manhiça, Mozambique

INTE-AFRICA

Integrating and decentralizing diabetes and hypertension services in Africa

AVATAR

Searching the hidden: evaluating dengue, chikungunya and Zika autochthonous transmission in the city of Barcelona.

COVID-PREG

Eficacia de hidroxicloroquina en la prevención de la infección por SARS-CoV-2 y de la gravedad de la enfermedad de COVID-19 durante el embarazo

AMR DetecTool

A breakthrough device for the rapid detection of antimicrobial resistance

ANTICOV

Large Clinical Trial in Africa on the Treatment of Mild Cases of COVID-19

HBV-COMSAVA

Hepatitis B Virus COMmunity Screening and Vaccination in Africans

Stool4TB

Evaluating a new stool based qPCR for diagnosis of tuberculosis in children and people living with HIV

Hep C Free Baleares

Eliminating hepatitis C on the Balearic Islands (Mallorca, Menorca and Ibiza): a study in governmental and non-governmental addiction service centres, a mobile methadone unit and a prison to test and link people who use drugs to HCV care.

STREESCO

Strengthening Epidemiological Surveillance in Benin and Burkina Faso for an Effective Response to COVID-19

COVAIR-CAT

Air Pollution in Relation to COVID-19 Morbidity and Mortality: A Large Population-Based Cohort Study in Catalonia

TB-RECONNECT

Reconnecting Transmission to Global Tuberculosis Control by Mapping Pathogen Transmission Events to Host Infection Status

SToolNIH

Quantifiable stool-based TB PCR to Improve Diagnostics and Treatment Monitoring

END-VOC

ENDing COVID-19 Variants Of concern through Cohort studies (END-VOC)