- June 2017-December 2018
- Alberto García Basteiro (ISGlobal)
- STOP TB Alliance
Mozambique is hard hit by the TB epidemic. The annual TB incidence rate is 551 cases per 100000 population. The estimated low TB case detection rate (CDR) of 39% urgently demands sustainable active case finding (ACF) interventions and broad implementation of improved diagnostics, among others.
Several bottlenecks have been identified to affect the low TB CDR. The majority of the population lives in rural areas with poor road and transport infrastructure. Distance to health centres is a commonly reported factor causing nonadherence to the national TB care recommendations. In addition, high poverty levels are an added obstacle for accessing care.
People living with HIV (PLHIV) are thought to endure most of the TB burden. TB diagnosis among PLHIV is challenging, and sputum smear remains the main TB diagnostic test. This might greatly contribute to the low CDR, given that HIV prevalence among adults in the region could be as high as 40%. Moreover, high rates of TB in children and low paediatric CDR also support the implementation of ACF strategies. Misperceptions about TB have been linked to underdiagnosis or delayed diagnosis in the region. In addition, poor training of health workers can contribute to inadequate TB diagnosis and impact case notification.
The overall purpose of this project is to increase the number of TB diagnoses in Manhiça district, a high TBHIV burden area in Southern Mozambique. We will implement an active case finding (ACF) strategy, which uses a TB contact definition based on Xpert MTB/RIF semiquantitative results, as a proxy of index case infectiousness, and spatial parameters. This strategy will contribute to improving TB case detection and reducing TB transmission.
Government of Canada and Bill & Melinda Gates Foundation through the STOP TB Alliance.
Principal Investigator (PI)
- Alberto García-Basteiro Assistant Research Professor
Otros proyectosVer proyectos pasados
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Erradicación del Pian
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Prioritising Antimicrobial Resistance: establishing an interdisciplinary International Research Partnership to tackle an evolving global health threat
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Non-invasive ultrasound-based screening for meningitis: Proof-of concept in infants
Evaluation of the effect of weekly high dose rifapentine and isoniazid (3HP) vs periodic 3HP vs 6H for preventing TB among HIV-positive individualshttps://clinicaltrials.gov/ct2/show/NCT02980016
Search for new target proteins and use of antibacterial or inhibitory peptides against resistance mechanisms in 'Acinetobacter baumannii'
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Optimizing provider-initiated HIV testing, linkage, and retention in care in the district of Manhiça, Mozambique
Integrating and decentralizing diabetes and hypertension services in Africahttp://inteafrica.org/
Searching the hidden: evaluating dengue, chikungunya and Zika autochthonous transmission in the city of Barcelona.
Linkage and retention in care following home-based HIV testing serosurveys in Manhiça District, Southern Mozambique
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Improving Maternal and Infant Health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant womenwww.mamahproject.net