Publicador de contenidos

Resistencia antimicrobiana

Nuevos agentes contra bacilos gram-negativos

Nuevos enfoques para el diseño de agentes antibacterianos activos frente a bacilos gram-negativos multirresistentes

Jan 01, 2015 - Dec 31, 2018
Ministerio de Ciencia, Innovación y Universidades. Instituto de Salud Carlos III, Unión Europea. This project is co-funded by the Fondo Europeo de Desarrollo Regional (FEDER). “Una manera de hacer Europa”.

Currently a large partion of available antibiotics are not suitable for the treatment of multiresistant pathogens. Sometimes the choice of treatment is reduced to a single drug, such as colistin for P. aeruginosa and Acinetobacter. The lack of profitability has led to a decline in R+D for new antibiotics by the pharmaceutical industry. There is therefore a clear need for new antibacterial agents, mainly against multi-resistant Gram-negative bacilli.

The main objective of this project is the design of new antibacterial agents against P. aeruginosa, A. baumannii and K. pneumoniae by various approaches:

1. Characterization of potential inhibitors of efflux systems, we have found by docking, 50 compounds (from two libraries of compounds) that potentially can inhibit efflux pumps. These compounds will be characterized in detail.

2. To optimize peptides with activity against the organisms being studied. We have 18 antibacterial peptides with potential capacity and its stability and toxicity will be studied. Of those the three peptides with increased activity and stability and less toxicity, the "in vivo" activity will be investigated;

3. Characterization of two-component systems (TCS). By analysis "in silico" found 41 potential TCS in A. baumannii. The aim is to study its involvement in virulence and essentiality, in order to find possible inhibitors that would have antibacterial activity and antivirulencia; 

4. Design and study of the antibacterial activity of peptide-oligonucleotide and siderophore-oligonucleotide hybrids. Oligonucleotides inhibit mRNA expression of some essential genes, whereas either peptide or siderophor will be used as transport systems across the cell wall. Once designed these hybrids will be tested both "in vitro" and "in vivo".

Total funding

184,827.50 €

Project Code


Nuestro equipo

ISGlobal team

  • Jordi Vila Estape
    Jordi Vila Estape

Otros proyectos

Ver proyectos pasados


Combatiendo la Resistencia Bacteriana en Europa


Development of Novel Gastrointestinal Biomarkers for Use in HIV Incidence Determination in a Sub-Saharan African Setting


Combatting Bacterial Resistance in Europe - Carbapenem Resistance


Improving Maternal and Infant Health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women


Integrating and decentralizing diabetes and hypertension services in Africa


Improving Care through Azithromycin Research for Infants in Africa


Predicting the Future: Incipient Tuberculosis


Large Clinical Trial in Africa on the Treatment of Mild Cases of COVID-19


Evaluating a new stool based qPCR for diagnosis of tuberculosis in children and people living with HIV


Reconnecting Transmission to Global Tuberculosis Control by Mapping Pathogen Transmission Events to Host Infection Status


Quantifiable stool-based TB PCR to Improve Diagnostics and Treatment Monitoring


ENDing COVID-19 Variants Of concern through Cohort studies (END-VOC)


Digital Twins Enabled Indoor Air Quality Management for Healthy Living


Community knowledge generation through scientific culture, urban ecology and art


Building Scalable Pathogen Genomic Epidemiology in Ethiopia

Hepatitis C Free Baleares

Eliminating hepatitis C on the Balearic Islands (Mallorca, Menorca and Ibiza): a study in governmental and non-governmental addiction service centres, a mobile methadone unit and a prison to test and link people who use drugs to HCV care.


Nuevas moléculas de oro coordinadas con flavonoides contra bacterias patógenas multirresistentes prioritarias