Publicador de contenidos

Investigación e Innovación Programas
Salud Materna, Infantil y Reproductiva

METRO

Measuring community prevalence among HIV exposed children in rural Southern Mozambique

Foto: ISGlobal
Duración
01/09/2017 - 31/08/2019
Coordinador
Denise Naniche
Financiadores
PEPFAR, Centers for Disease Control and Prevention

Mozambique’s national prevention of mother to child transmission of HIV (PMTCT) program was established in 2002 and rapidly expanded. In June 2013, the Ministry of Health launched WHO Option B+, which offers antiretroviral treatment for life to all HIV positive pregnant women. By the end of 2014, 742 health units were offering B+ out of 1272 health facilities offering PMTCT services.

In light of these efforts, Mozambique has achieved a rapid reduction in new child HIV infections, from 27,000 in 2009 to 12,000 in 2013. UNAIDS estimates that the country’s MTCT rate has decreased from 26% in 2009 to 12% in 2013. However, reliable measures of final MTCT rates after breastfeeding cessation are not available. Obtaining this information is challenging due to low retention in the PMTCT cascade. Also, though prolonged breastfeeding is common in Mozambique, we have no reliable information on duration of breastfeeding among HIV-exposed infants and children. 

In order to begin assessing the impact of PMTCT efforts to date and obtain baseline information for further improvement of PMTCT programs, a programmatic evaluation to measure community HIV prevalence among HIV-exposed children after cessation of breastfeeding is urgently needed in Mozambique.

Objectives

The main objective of the METRO study is to estimate the prevalence of HIV in exposed children under 4 years of age in the community, after cessation of breastfeeding, in Southern rural Mozambique in the period between 2012 and 2016.

More specifically, the project aims:

  • To describe characteristics linked with child HIV exposure and HIV vertical transmission
  • To estimate the duration of breastfeeding in the population of Manhiça district and to describe demographic, health, economic, and socio-cultural, characteristics of breastfeeding women
  • To estimate mortality among HIV-positive mothers and HIV-exposed children

The project takes place within a demographic surveillance platform in Manhiça and offers testing and counseling to women and their children, identifying children exposed to HIV 48 months or younger.

Impact

The results obtained from this study will provide baseline data at subnational level that can later be used to estimate trends; and also used to initiate the elimination of mother-to-child transmission (EMTCT) pre-validation process according to WHO criteria. Furthermore it will be used to inform planning of national PMTCT program activities including potential community outreach programs, among other applications.  

Total funding

300,000 USD

Nuestro equipo

Principal Investigator

  • Denise Suzanne Naniche
    Denise Suzanne Naniche

ISGlobal team

Otros proyectos

Ver proyectos pasados

COMBACTE

Combatiendo la Resistencia Bacteriana en Europa

GAMA

Development of Novel Gastrointestinal Biomarkers for Use in HIV Incidence Determination in a Sub-Saharan African Setting

COMBACTE-CARE

Combatting Bacterial Resistance in Europe - Carbapenem Resistance

MAMAH

Improving Maternal and Infant Health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women

INTE-AFRICA

Integrating and decentralizing diabetes and hypertension services in Africa

ICARIA

Improving Care through Azithromycin Research for Infants in Africa

PreFIT

Predicting the Future: Incipient Tuberculosis

ANTICOV

Large Clinical Trial in Africa on the Treatment of Mild Cases of COVID-19

Stool4TB

Evaluating a new stool based qPCR for diagnosis of tuberculosis in children and people living with HIV

TB-RECONNECT

Reconnecting Transmission to Global Tuberculosis Control by Mapping Pathogen Transmission Events to Host Infection Status

SToolNIH

Quantifiable stool-based TB PCR to Improve Diagnostics and Treatment Monitoring

END-VOC

ENDing COVID-19 Variants Of concern through Cohort studies (END-VOC)

TwinAir

Digital Twins Enabled Indoor Air Quality Management for Healthy Living

ENDÈMIC

Community knowledge generation through scientific culture, urban ecology and art

EpiGen

Building Scalable Pathogen Genomic Epidemiology in Ethiopia

Hepatitis C Free Baleares

Eliminating hepatitis C on the Balearic Islands (Mallorca, Menorca and Ibiza): a study in governmental and non-governmental addiction service centres, a mobile methadone unit and a prison to test and link people who use drugs to HCV care.

CaDMIA-plus

Validación continuada de la autopsia mínimamente invasiva (MIA) para la investigación de la causa de muerte en niños pequeños, y desarrollo de un centro de investigación y formación sobre el estudio de la causa de muerte

MIBio

Identification of Prematurity and Pre-Eclampsia as Causes of Mortality

MULTIPLY

MULTIple doses of IPTi Proposal: a Lifesaving high Yield intervention

MA-CoV

Prevalence and impact of SARS-CoV-2 infection on maternal and infant health in African populations

IPERVAC-SL

Impact of perceptions of COVID-19 vaccines on health-seeking behaviours in Sierra Leone

RESPIRE

Respiratory syncytial virus (RSV) in African pregnant women and children

VITAL

Towards preparedness for new maternal vaccinations: Understanding barriers and facilitators to maternal vaccine acceptance

HIV drug resistance (HIVDR)

Description of HIV drug resistance patterns and its association with the risk of HIV mother to child transmission among pregnant women from southern Mozambique