- Quique Bassat
- ISCIII (FIS programme)
165 newborns die every day of Bacterial Meningitis (BM), an aggressive infection that leaves severe sequelae among 30% of survivors. Rapid detection, particularly in this age group, is difficult due to the little specificity and overlap of its symptoms with those of more common and less severe diseases.
Our objective is to continue with the development and validation of a prototype to non-invasive screening for meningitis. Early diagnosis by means of a lumbar puncture (LP), invasive and potentially harmful procedure, and prompt antibiotic treatment is the current strategy to improve prognosis of this devastating infection. A sample of cerebrospinal fluid (CSF) is drawn by means of a LP to obtain a white blood cell (leucocytes) count, that, if elevated, confirms the need for immediate treatment while waiting for bacteriologic results available after 24-48h. However, about 95% of the 8.000 LPs performed in young infants with fever of unknown source and suspected for BM result negative, raising Spanish hospital costs in 25M€. In resource-constrained countries lacking laboratory facilities to analyse the sample, LPs are under-performed in spite of the high incidence of the infection in this context, raising neonatal mortality up to 50%.
We propose to use high-frequency ultrasounds to non-invasively count CSF cell concentration through the fontanel, the area of the infant head where the bones are not yet fused. A portable and easy-to-use device could reduce the number of unnecessary LPs, associated costs, and help save lives in under-resourced countries.
Otros proyectosVer proyectos pasados
Combatiendo la Resistencia Bacteriana en Europa
Erradicación del Pianhttp://pian.isglobal.org
Application to medical deviceswww.nomorfilm.eu
Combatting Bacterial Resistance in Europe - Carbapenem Resistancehttps://www.imi.europa.eu/content/combacte-care
Prioritising Antimicrobial Resistance: establishing an interdisciplinary International Research Partnership to tackle an evolving global health threat
An interdisciplinary International Research Partnership to tackle an evolving global health threat
Development of new metal-antibiotics against pathogens causing chronic infections in patients with cystic fibrosis.
New metal-antibiotics for patients with cystic fibrosis
Improved case detection through TB contact risk stratification by Xpert results and spatial parameters in Mozambique
Evaluation of the effect of weekly high dose rifapentine and isoniazid (3HP) vs periodic 3HP vs 6H for preventing TB among HIV-positive individualshttps://clinicaltrials.gov/ct2/show/NCT02980016
Search for new target proteins and use of antibacterial or inhibitory peptides against resistance mechanisms in 'Acinetobacter baumannii'
Desarrollo de nuevos metaloantibióticos frente a patógenos causantes de infecciones crónicas en pacientes con fibrosis quística
Optimizing provider-initiated HIV testing, linkage, and retention in care in the district of Manhiça, Mozambique
Integrating and decentralizing diabetes and hypertension services in Africa
Searching the hidden: evaluating dengue, chikungunya and Zika autochthonous transmission in the city of Barcelona.