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Exosomes for neglected diseases

Exosomes: new intercellular communicators and their applicability as therapeutic agents in neglected parasitic diseases

Duration
07/04/2015-06/04/2018
Coordinator
Hernando A. del Portillo
Funded by
Fundació Ramón Areces

Parasitic diseases have affected humans since their emergence on Earth. These include diseases related to poverty such as malaria caused by Plasmodium vivax, Chagas disease caused by Trypanosoma cruzi and fascioliasis caused by F. hepatica.

We hypothesize that exosomes derived from these three human infections act in inter-cellular communication facilitating the establishment of infections. Moreover, the parasite-specific proteins associated with these exosomes will permit the identification of new antigens for vaccination, and the use of human reticulocyte-derived exosomes will serve as a new vehicle for antigen delivery and presentation to develop vaccines against these neglected tropical diseases.

This is a joint-project  with Drs. Antonio Osuna (U. de Granada) and Antonio Marcilla (U. de Valencia) funded through the Fundación Ramón Areces.

Total funding

122,688.86 €

 

Our Team

Principal Investigator

  • Hernando Del Portillo Obando
    Hernando Del Portillo Obando

ISGlobal Team

  • Maria Carmen Fernandez Becerra
    Maria Carmen Fernandez Becerra
  • Joan Seguí
    Joan Seguí
  • Marc Nicolau
    Marc Nicolau Técnico de Laboratorio

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