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LIFEBRAIN

Lifestyle contributors to brain resilience

Photo: Canva

Duration: 16/02/2023 - 28/02/2024
Coordinator: Eider Martínez de Arenaza Urquijo
Funded by: Ministerio de Ciencia, Innovación e Universidades (Ayuda PID2019-111514RA-100)

The general objectives of the proposal are to identify modifiable factors and brain mechanisms that act to increase:

Resistance to Alzheimer’s disease (AD) pathologies - amyloid and tau - and/or
Brain vulnerability/resilience - measured as loss/preservation of neural integrity - during midlife
Assessing their association with cognitive change

The specific objectives of the present proposal are as follows:

1.1. To assess the associations of baseline and longitudinal changes on amyloid and tau with proximity to parental age at onset

1.2. To assess the role of modifiable factors on these associations

2.1. To develop an imagingbased approach to measure vulnerability/resilience

2.2. To quantify the effects of multiple modifiable factors on vulnerability/resilience measurements

3.1. To identify the combination of factors that best predict cognitive decline

Total Fuding

39.881,67 €

Coordinator

Eider Arenaza-Urquijo Assistant Research Professor

ISGlobal Team

Müge Akinci Pre-doctoral Fellow

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LIFEBRAIN