I4C (International Childhood Cancer Cohort Consortium)

Duration
2005-
Coordinator
WESTAT (with Harvard Medical School, University of Pennsylvania, and Daston Communications)
Funded by
NICHD/NIH/HHS
NIEHS/NIH/HHS
CDC/HHS
EPA
Globally, a number of large infant/child prospective studies have been launched to examine environmental and genetic determinants of common diseases of children, such as asthma, developmental delay and behaviour abnormalities, as well as the consequences of early exposure for adult diseases. While several of these studies are relatively very large—over 100 000 subjects—and are adequately powered to examine their principal outcomes of interest, none of the individual studies are of sufficient size to examine the relationship between exposures they are measuring and rare diseases such as childhood cancer. To date, the few established risk factors for specific forms of childhood cancer have largely been identified in case-control studies. Yet, despite many such investigations evaluating postulated risk factors for paediatric malignancies during the past five decades, few consistently established aetiologic factors are known (Brown et al, IJE 2007, click here for access to a paper).

The I4C was established in 2005 and brings together large cohorts from several countries. CREAL participates in the steering committee (M Kogevinas) and also contributes with data from INMA and RHEA cohorts. CREAL is actively involved in the development of the protocols of one of the two main areas, specifically environmental exposures. After the last meeting (IARC, November 2009 click here to read minutes of the meeting) both an environmental and a genomics working groups were established. The environmental group should develop protocols on specific exposures including chemicals, radiations and others.

For further information: http://www.nationalchildrensstudy.gov/research/internationalinvolvement/Pages/childhoodcancercohortconsortium.aspx

 

Our Team

Principal Investigator (PI)

Other projects

See Past Projects

MCC-Spain

Population based multicasecontrol study on common tumours in Spain

PROactive

Physical Activity as a Crucial Patient Reported Outcome in COPD

OMEGA-NET

Network on the Coordination and Harmonisation of European Occupational Cohorts

POLLAR

Impact Of Pollution on Asthma and Rhinitis

CORSAIR

Severe respiratory failure in COVID-19: clinical, biological and imaging risk factors

VEIS

Leveraging the European Genome-Phenome Archive (EGA) for Industry and Society

Mobilise-D

Connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement

COVICAT

Cohorte Covid-19 en Cataluña

EARLY-ADAPT

Signs of Early Adaptation to Climate Change

AiguaBCN

Exposure to emerging contaminants in drinking water in Barcelona potentially liked to chronic diseases and wellbeing

Fotovoz

Las Voces de los Afectados por la Nefropatía Mesoamericana

CALMA

Co-created educational programme for dyspnea-bearing patients and their caregivers

Cancer-Watch

Risk of colorectal and breast cancer with widespread drinking water chemical contaminants

CONTENT

Cohort of COVID-19 in Spain: social dynamics, mental health and inequalities

EXPANSE

EXposome Powered tools for healthy living in urbAN SEttings

COVAIR-CAT

Air Pollution in Relation to COVID-19 Morbidity and Mortality: A Large Population-Based Cohort Study in Catalonia