Asset Publisher

Epidemiologia molecular de la función pulmonar: un abordaje integral

Duration
2010-2012
Coordinator
Stefano Guerra
Funded by
Fondo de Investigación Sanitaria (FIS)
It has been long known that levels of lung function are a strong predictor of functional impairment, reduced quality of life, overall mortality.These associations are mostly related to the deleterious health effects of chronic obstructive pulmonary disease (COPD).Although most patients develop COPD in their middle to late adult life, the acceleration of decline of lung function that will lead to the development of the disease usually starts in young adulthood. Thus, the identification of systemic biomarkers of decline of lung function in young adult life could provide insights into the molecular mechanisms of early susceptibility to COPD and have critical implications for prevention. In this application, we propose to use the Spanish branch of the prospective population-based ECRHS study (N = 1.595) that provides detailed respiratory phenotypic information and an extensive collection of serum samples and DNA. In serum, we will test with the Luminex-based MAP technology and with ELISA a panel of 14 biomarkers variably involved in inflammation (IL- 1beta, IL-6, IL-8, TNF-alpha, CRP), innate immunity (sCD14), proteolysis (alpha1 antitrypsin,TIMP1, MMP3), oxidative stress (myeloperoxidase), auto-immune responses (anti-elastin antibodies) and other potential pathways (YKL-40, CC-16, SP-D). A large group of candidate genes related to the above biomarkers will be also genotyped. Ultimately, levels of biomarkers and genetic variants will be prospectively tested against levels and decline of lung function.

Our Team

Principal Investigator (PI)

Other projects

See Past Projects

MCC-Spain

Population based multicasecontrol study on common tumours in Spain

HELIX

Novel tools for integrating early-life environmental exposures and child health across Europe

EGG/EAGLE

Early Genetics Growth/Early Genetics and Lifecourse Epidemiology

PACE

Pregnancy and Childhood Epigenetics

LIFECYCLE

Early-life stressors and LifeCycle health

OMEGA-NET

Network on the Coordination and Harmonisation of European Occupational Cohorts

HARMONIC

Health effects of cArdiac fluoRoscopy and mOdern radIotherapy in paediatriCs

Mobilise-D

Connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement

EARLY-ADAPT

Signs of Early Adaptation to Climate Change

COVICAT

Cohorte Covid-19 en Cataluña

ATHLETE

Advancing Tools for Human Early Lifecourse Exposome Research and Translation

CONTENT

Cohort of COVID-19 in Spain: social dynamics, mental health and inequalities

EUCAN-Connect

A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health

OBERON

An integrative strategy of testing systems for identification of EDs related to metabolic disorders

EXPANSE

EXposome Powered tools for healthy living in urbAN SEttings

AURORA 2021

Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics

ONES

Fine Particle Matter, Fetal Growth, and Neurodevelopment: Examining Critical Windows of Susceptibility

AIR-NB

Pre-natal exposure to urban AIR pollution and pre- and post-Natal Brain development

NutinBrain

The role of seafood and nut consumption on human neurodevelopment from pregnancy to adolescence

UrbanKids

Urban and social environment and childhood obesity – a natural moving2health experiment

iGenCO

In-Depth Genomics and Cross-Omics Analysis for Undiagnosed Rare Diseases on a User-Friendly Collaborative Platform

CityExposomeCat

An Exposome Approach to Urban Health: Individualized Environmental Exposure Assessment in an Adults Population Cohort Study (GCAT)

TwinAir

Digital Twins Enabled Indoor Air Quality Management for Healthy Living

UBDPOLICY

The Urban Burden of Disease Estimation for POLICY Making

TOLIFE

Combining Artificial Intelligence and smart sensing TOward better management and improved quality of LIFE in chronic obstructive pulmonary disease

BWater

Drinking Water in Barcelona: Sustainability and Health Impact Assessment

intoDBP

Innovative Tools to Control Organic Matter and Disinfection Byproducts in Drinking Water

FINDOOR

FTIR spectroscopy for real-time detection of bacterial outbreaks and the rapid identification of pathogenic serotypes, relapsing infections and antibiotic resistance

OccRF-Health

Occupational exposure to radiofrequency electromagnetic fields: From exposure assessment to study of health in workers and their offspring

EPHOR

Exposome Project for Health and Occupational Research

EXPONIT

Analysing and studying how night shift work affects workers' circadian rhythms and health

IHEN

International Human Exposome Network

B-Triage

Una prueba en el punto de atención para la estratificación del riesgo de los pacientes febriles basada en los niveles de sTREM-1

e-QuoL

e-health tools to promote Equality in Quality of Life for childhood to young adulthood cancer patients, survivors and their families

null