Recerca

ExPEC-TEEN

Prenatal Exposure to Environmental Pollutants and Metabolic and Cardiovascular Health of the Teenagers

Projecte ExPEC-TEEN
Foto: Gaelle Marcel / Unsplash
Durada
13/11/2019 - 13/07/2023
Coordinador
Charline Warembourg
Finançadors
ANSES (Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail, France)

Aim

The general objective of ExPEC-TEEN is to study the effect of early-life exposure to environmental contaminants, especially chemicals with endocrine-disrupting activities (EDCs), on metabolic and cardiovascular outcomes in adolescents.

Challenges

ExPEC-TEEN will go beyond the limitations of previous studies and fill the current gaps by:

  • improving the phenotype characterization;
  • following children longitudinally from in utero life period until adolescence; and
  • taking into account a wide range of EDCs during pregnancy.

Methods

The program of ExPEC-TEEN aims at conducting a new and harmonized follow-up of the participants enrolled in the PELAGIE (France) and INMA-Sabadell (Spain) cohorts, at the teen ages.

The protocol will include a clinical examination of the child at 15-17 years for anthropometric and cardiovascular measurements, and a fasting blood sample collection. More specifically, metabolic health of the adolescent will be assessed by anthropometric measures and biological markers of dyslipidaemia, insulin resistance, and transaminases, and cardiovascular health will be assessed using a classical measure of blood pressure and novel markers characterizing arterial stiffness and microcirculation through the measure of the pulse wave velocity and the diameter of the retinal vessels.

Advanced statistical methods will be used to evaluate the simultaneous effect of prenatal exposure to a wide range of chemicals.

Impact

Benefiting from the longitudinal collection of health and environmental data from the perinatal period in the PELAGIE and INMA-Sabadell cohorts, the project will provide important findings for public health with potential recommendations for health promotion and for disease prevention strategies.

A more exhaustive evaluation of cardiometabolic outcomes in adolescence would allow a better understanding of the early age processes most affected by environmental factors. Furthermore, the study of a wide range of chemicals would improve knowledge on the health effects of low-dose and mixture of exposure to EDCs.

Funding

Total: 199,864 €

ISGlobal: 67,447 €

Our Team

Coordinator

ISGlobal Team

Altres projectes

Veure projectes passats

EGG/EAGLE

Early Genetics Growth/Early Genetics and Lifecourse Epidemiology

PACE

Pregnancy and Childhood Epigenetics

APACHE

Air Pollution, Autism spectrum disorders, and brain imaging in CHildren amongst Europe

LIFECYCLE

Early-life stressors and LifeCycle health

ATHLETE

Advancing Tools for Human Early Lifecourse Exposome Research and Translation

MOOD-COVID

Pre- and post-natal Maternal mental health and newbOrn neurOdevelopment during the COVID-19 panDemic

EUCAN-Connect

A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health

OBERON

An integrative strategy of testing systems for identification of EDs related to metabolic disorders

The Lungfit Project

Socioeconomic Status, Physical Activity, and Respiratory Health in Pregnant Women, Children, and Adolescents

AURORA 2021

Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics

HELIX-NAFLD

Developmental origins of child liver injury: the effect of early life environmental exposures

UrbaMet

Entorno Urbano y Salud Cardiometabólica desde el Nacimiento hasta la Adolescencia

NutriPROGRAM

Early-life Nutritional Programming of Metabolic Health through Epigenetic Pathways

ELHNA

Exposures to light pollution and heat, and neurodevelopment in adolescents

ONES

Fine Particle Matter, Fetal Growth, and Neurodevelopment: Examining Critical Windows of Susceptibility

AIR-NB

Pre-natal exposure to urban AIR pollution and pre- and post-Natal Brain development

FRONTIER

Traffic-Related Air Pollution and Birth Weight: the Roles of Noise, Placental Function, Green Space, Physical Activity, and Socioeconomic Status

The APBO Project

Air Pollution and Birth Outcomes: Windows of Exposure and Health and Economic Impact Assessment

INMA-Ado-Sueño

Radio Frequency Electromagnetic Fields, Noise, and Sleep Disorders in Adolescence

ANSES HyPAXE

Prenatal Exposure to a Family of Short Half-Life Endocrine Disruptors, Dysregulation of the Hypothalamic–Pituitary–Adrenal Axis and Potential Implication for Child Neurodevelopment at Early Age

EXPO-ENFANTS

Caractérisation des usages et de l’exposition aux radiofréquences induite par les dispositifs de communication mobiles chez les enfants

Lily

Light at Night Exposure and Sleep Quality

EMBRYORAD

Radiofrequency Electromagnetic Fields, Other Environmental Factors, and Development of the Embryo and Fetus

IGRO

The Impact of Maternal-Fetal Steroid Metabolome Exposure on Child GROwth and Neurological Outcomes

NutinBrain

The role of seafood and nut consumption on human neurodevelopment from pregnancy to adolescence