Exosomes for neglected diseases
Exosomes: new intercellular communicators and their applicability as therapeutic agents in neglected parasitic diseases
- Durada
- 07/04/2015-06/04/2018
- Coordinador
- Hernando A. del Portillo
- Finançadors
- Fundació Ramón Areces
Parasitic diseases have affected humans since their emergence on Earth. These include diseases related to poverty such as malaria caused by Plasmodium vivax, Chagas disease caused by Trypanosoma cruzi and fascioliasis caused by F. hepatica.
We hypothesize that exosomes derived from these three human infections act in inter-cellular communication facilitating the establishment of infections. Moreover, the parasite-specific proteins associated with these exosomes will permit the identification of new antigens for vaccination, and the use of human reticulocyte-derived exosomes will serve as a new vehicle for antigen delivery and presentation to develop vaccines against these neglected tropical diseases.
This is a joint-project with Drs. Antonio Osuna (U. de Granada) and Antonio Marcilla (U. de Valencia) funded through the Fundación Ramón Areces.
Total funding
122,688.86 €
Our Team
Principal Investigator
-
Hernando Del Portillo Obando
ISGlobal Team
-
Maria Carmen Fernandez Becerra
-
Joan Seguí
-
Marc Nicolau Técnico de Laboratorio
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