- 2010 - 2015
- Josep M. Antó
- Página web
Allergic diseases (asthma (A), rhinitis (R) and eczema(E)) are complex and associated with allergen-specific IgE and non-allergic mechanisms that may coexist in the same patient (multimorbidity of A, R & E). MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) was launched to generate novel knowledge on the mechanisms of initiation of allergy from early childhood to young adulthood. MeDALL linked epidemiological, clinical and basic research. It was based on a novel, stepwise, large-scale and integrative approach led by a network of complementary experts in allergy, epidemiology, allergen biochemistry, immunology, molecular biology, epigenetics, functional genomics, bioinformatics, computational and systems biology.
- Identification of “classical” and “novel” phenotypes in existing birth cohorts
- Building discovery of the relevant mechanisms in IgE-associated allergic diseases in existing longitudinal birth cohorts;
- Validation and redefinition of classical and novel phenotypes of IgE-associated allergic diseases, and
- Translational integration of systems biology outcomes into healthcare, including societal aspects.
- Multimorbidity of A, R & E is more common than expected by chance alone suggesting that the diseases share causal mechanisms.
- Using unsupervised cluster analysis at 4 and 8 years, two groups were identified suggesting that asthma, rhinitis and eczema can be classified together as an allergic comorbidity cluster.
- A computational analysis of the topology of the protein interaction network shows that asthma, eczema and rhinitis share a larger number of associated proteins than expected by chance.
- A targeted proteomic approach allowed to assess the role of several candidates including CC16 and YKl-40 of asthma and allergy related phenotypes in children. Identifying a potential novel biomarker of asthma and the role of systemic inflammation in allergic multimorbidities in early childhood, both using the classical and novel phenotypes.
- As part of the translational efforts in MeDALL a systematic review of characteristics of risk prediction models to identify preschool children with asthma-like symptoms who will develop clinical asthma at school age. Twelve prediction models were identified.
Josep Mª Antó Research Professor
Jordi Sunyer Jefe del Programa de Infancia y Medio Ambiente
Marta Benet Técnica estadística
Judith Garcia Jefa del programa de Enfermedades no transmisibles y medio ambiente
Stefano Guerra Visiting Scholar
Anne-Elie Carsin Técnica estadística
Mariona Bustamante Staff Scientist
Xavier Basagaña Associate Research Professor
Manolis Kogevinas Director científico de la distinción Severo Ochoa
Juan R. González Associate Research Professor
Otros proyectosVer proyectos pasados
Estudio multi-caso control poblacional, incluyendo tumores de alta incidencia en Españahttp://www.mccspain.org/
Aging Lungs in European Cohortshttp://www.alecstudy.org/
Physical Activity as a Crucial Patient Reported Outcome in COPDhttps://www.imi.europa.eu/content/pro-active
Onset and progression determinants of COPD in young adults
Social and environmental determinants of physical activity in patients with chronic obstructive pulmonary disease (COPD): a qualitative and quantitative epidemiological study
Network on the Coordination and Harmonisation of European Occupational Cohortshttp://www.omeganetcohorts.eu
Impact Of Pollution on Asthma and Rhinitishttps://www.eithealth.eu/pollar
Integrating Environment and Health Research: a Vision for the EUhttps://www.heraresearcheu.eu
Towards the elimination of iodine deficiency and preventable thyroid-related diseases in Europehttp://euthyroid.eu/
Early Genetics Growth/Early Genetics and Lifecourse Epidemiology
Air Pollution, Autism spectrum disorders, and brain imaging in CHildren amongst Europe
Urban environment and childhood obesity in Catalonia
Endocrine Disruptors and Childhood Lung Function and Asthma
Early-life stressors and LifeCycle healthhttp://www.lifecycle-project.eu
Ventanas de vulnerabilidad pre-natal y post-natal en el riesgo de retraso en el neurodesarrollo asociado a la contaminación particulada del aire
Long-chain Polyunsaturated Fatty Acids and Adolescent Brain Development: A Dietary Intervention
Exposiciones ambientales a edad temprana y riesgo cardiovascular del adolescente
ÁCIDOS GRASOS, POLUCIÓN ATMOSFÉRICA Y DESARROLLO NEUROPSICOLÓGICO
Science and Technology in childhood Obesity Policyhttp://stopchildobesity.eu