- 01/01/2018 - 31/12/2018
- Centre aux Energies Atomiques (CEA), France
- EIT Health (Innovation by Ideas)
The increasing rates of infections caused by broad-spectrum β-lactamases (ESBLs and carbapenemases)-producing Enterobacteriaceae is a major public health concern.
To fight efficiently against the emergence and the spread of these multidrug (sometimes even pandrug) resistant bacteria, rapid detection and characterization is a prerequisite to implement proper hygiene and infection control measures, as well as a more adequate empirical treatment. Several methods already exist to detect antimicrobial resistance but these techniques require isolated bacteria and procedures with non-compatible delays (≥16 hours).
Thus, sensitive, rapid, low cost and user-friendly tests need to be implemented in clinical microbiology laboratories. Due to its characteristics the lateral flow immunoassay (LFIA) matches perfectly with these specifications.
The aim of this project is to validate a diagnostic tool using the LFIA technology for the detection of broad spectrum β-lactamases (CTXM) and carbapenemases (OXA; NDM; KPC, VIM, IMP) directy from biological samples.
We will develop a test consisting of a nitrocellulose strip, which allows the immunological detection, enclosed in a plastic device, which carries out sample treatment. The devices, produced by 3D printing, will be optimized and validated with real clinical samples.
The operational procedures will be improved to fit with clinical habits and analytical specifications (specificity, reproducibility and sensitivity) and a cost-effectiveness analysis will be carried out.
At the end of this project a business concept will be established and training tools for
end-users will be available to accelerate the industrial transfer of this technology and
its implementation in care facilities.
Otros proyectosVer proyectos pasados
A breakthrough device for the rapid detection of antimicrobial resistance
Combatiendo la Resistencia Bacteriana en Europa
Erradicación del Pian
Application to medical devices
Combatting Bacterial Resistance in Europe - Carbapenem Resistance
Prioritising Antimicrobial Resistance: establishing an interdisciplinary International Research Partnership to tackle an evolving global health threat
An interdisciplinary International Research Partnership to tackle an evolving global health threat
Development of new metal-antibiotics against pathogens causing chronic infections in patients with cystic fibrosis.
New metal-antibiotics for patients with cystic fibrosis
Non-invasive ultrasound-based screening for meningitis: Proof-of concept in infants
Improved case detection through TB contact risk stratification by Xpert results and spatial parameters in Mozambique
Evaluation of the effect of weekly high dose rifapentine and isoniazid (3HP) vs periodic 3HP vs 6H for preventing TB among HIV-positive individuals
Search for new target proteins and use of antibacterial or inhibitory peptides against resistance mechanisms in 'Acinetobacter baumannii'
Optimizing provider-initiated HIV testing, linkage, and retention in care in the district of Manhiça, Mozambique
Integrating and decentralizing diabetes and hypertension services in Africa
Searching the hidden: evaluating dengue, chikungunya and Zika autochthonous transmission in the city of Barcelona.
Eficacia de hidroxicloroquina en la prevención de la infección por SARS-CoV-2 y de la gravedad de la enfermedad de COVID-19 durante el embarazo
Estudio piloto para evaluar el potencial de la ivermectina para reducir la transmisión de COVID-19
Cendea de Cizur
Conèixer la propagació. Entendre la protecció
Large Clinical Trial in Africa on the Treatment of Mild Cases of COVID-19
Hepatitis B Virus COMmunity Screening and Vaccination in Africans
Evaluating a new stool based qPCR for diagnosis of tuberculosis in children and people living with HIV
Eliminating hepatitis C on the Balearic Islands (Mallorca, Menorca and Ibiza): a study in governmental and non-governmental addiction service centres, a mobile methadone unit and a prison to test and link people who use drugs to HCV care.
Close the Gap, Increase Access, Provide Adequate Therapy
Strengthening Epidemiological Surveillance in Benin and Burkina Faso for an Effective Response to COVID-19
Air Pollution in Relation to COVID-19 Morbidity and Mortality: A Large Population-Based Cohort Study in Catalonia
Reconnecting Transmission to Global Tuberculosis Control by Mapping Pathogen Transmission Events to Host Infection Status
Quantifiable stool-based TB PCR to Improve Diagnostics and Treatment Monitoring
ENDing COVID-19 Variants Of concern through Cohort studies (END-VOC)