- 01/03/2019 - 29/02/2024
- Kristina Walker Whitworth (Baylor College of Medicine), Mònica Guxens (ISGlobal)
- National Institute of Health (NIH), USA
Air pollution is associated with a range of health outcomes; while historically, the focus has been on cardiopulmonary effects, recent toxicological and epidemiologic evidence indicates neurotoxic effects, especially of particulate matter (PM).
Pre- and post-natal exposure to PM has been associated with adverse child neurodevelopmental outcomes, though important questions regarding critical windows of exposure remain unanswered. Given the developmental potential of children (in addition to the fetus), exposure timing is critical in determining the specific nature of exposure-outcome relationships.
Lack of detailed exposure data (e.g., multiple individual-level exposure estimates over the life course) in large pediatric cohort studies hinders efforts to define the complex interplay of factors that determine child health and carefully examine hypotheses related to critical windows of susceptibility to environmental exposures. While in utero exposure to PM may have a direct effect on child neurodevelopmental outcomes, it is possible that this effect is moderated by (or in the case of prenatal exposures mediated through and moderated by) in utero fetal growth.
Thus far, the role of fetal growth in child neurodevelopment has been largely based on studies in children born preterm or small-for-gestational-age (SGA). While convenient and low cost, measures at birth do not capture the dynamic nature of fetal growth. Additionally, anthropometric measures at birth provide a particularly poor proxy of fetal growth during early pregnancy, which may be an important period of exposure for many environmental contaminants, such as air pollution.
- The primary goal of the proposed study is to evaluate critical windows of exposure to PM with aerodynamic diameter < 2.5 microns (PM2.5) on child cognitive function and behavioral outcomes at ages four and seven.
- The secondary goal of this study is to gain a better understanding of the role of fetal growth, and head growth in particular, in the causal pathway linking PM2.5 to child neurodevelopment.
This study will be conducted among children from the INMA (Spanish INfancia y Medio Ambiente) project, a network of birth cohorts in Spain. INMA is unique in includes extensive standardized and objective measures of child neurocognitive and behavioral outcomes at multiple time points, serial indicators of fetal growth (at least three ultrasounds per woman), and extensive residential and health histories. Many of these data are unavailable in other large childhood cohorts.
Given rapid development during fetal development, infancy and early childhood, a more complete understanding of the mechanism through which pre- and postnatal air pollution exposures affect child neurodevelopment, as well as potential windows of susceptibility, may inform interventions aimed at reducing early exposures and ultimately decreasing disease burden.
We propose capitalizing on a wealth of data collected in an established pregnancy cohort, utilizing new approaches for assessment and evaluation of estimates of individual residential PM2.5 exposures, and applying novel statistical methods to identify critical windows of susceptibility to PM2.5.
This study will address gaps that present critical barriers to our ability to translate models of child health into strategies for pediatric health promotion and disease prevention.
Otros proyectosVer proyectos pasados
Cardiovascular Health effects of Air pollution in Andhra Pradesh, India
Engaging Citizens in Science: Promoting the Viability of Participatory Sensing for Monitoring Air and Environmental Quality
Estudio Internacional de la Mente, Actividades y Entornos Urbanos en Barcelona
Signs of Early Adaptation to Climate Change
Impacto de la crisis sanitaria de la COVID-19 en la Actividad Física y la Salud Mental en España
Researching Environments that Magnify Health Everyday
Calor, Trabajo y Salud
Exposiciones a contaminación lumínica y calor y neurodesarrollo en adolescentes. Código de proyecto: PI20/01695
Re-imagining Environments for Connection and Engagement: Testing Actions for Social Prescribing in Natural Spaces
Las ciudades y la salud
Climate Action To Advance HeaLthY Societies in Europe
Calor, trabajo y salud: caracterización de la exposición, marcadores de salud y efectividad de intervenciones
Project Code: PI20/00608
Project Code: PI20/01116
EXPLICA - Uso del EXPosoma para eLucIdar los factores promotores del riesgo CArdiovascular en entornos urbanos
Project Code: PI21/00930
Early Genetics Growth/Early Genetics and Lifecourse Epidemiology
Pregnancy and Childhood Epigenetics
Air Pollution, Autism spectrum disorders, and brain imaging in CHildren amongst Europe
Early-life stressors and LifeCycle health
Science and Technology in childhood Obesity Policy
Advancing Tools for Human Early Lifecourse Exposome Research and Translation
Pre- and post-natal Maternal mental health and newbOrn neurOdevelopment during the COVID-19 panDemic
A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health
An integrative strategy of testing systems for identification of EDs related to metabolic disorders
Socioeconomic Status, Physical Activity, and Respiratory Health in Pregnant Women, Children, and Adolescents
Prenatal Exposure to Environmental Pollutants and Metabolic and Cardiovascular Health of the Teenagers
Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics
Developmental origins of child liver injury: the effect of early life environmental exposures
External and Internal Human Exposure in Urban EXposome
Entorno Urbano y Salud Cardiometabólica desde el Nacimiento hasta la Adolescencia
Early-life Nutritional Programming of Metabolic Health through Epigenetic Pathways
Pre-natal exposure to urban AIR pollution and pre- and post-Natal Brain development
Traffic-Related Air Pollution and Birth Weight: the Roles of Noise, Placental Function, Green Space, Physical Activity, and Socioeconomic Status
Air Pollution and Birth Outcomes: Windows of Exposure and Health and Economic Impact Assessment
Radio Frequency Electromagnetic Fields, Noise, and Sleep Disorders in Adolescence
Prenatal Exposure to a Family of Short Half-Life Endocrine Disruptors, Dysregulation of the Hypothalamic–Pituitary–Adrenal Axis and Potential Implication for Child Neurodevelopment at Early Age
Caractérisation des usages et de l’exposition aux radiofréquences induite par les dispositifs de communication mobiles chez les enfants
Light at Night Exposure and Sleep Quality
Radiofrequency Electromagnetic Fields, Other Environmental Factors, and Development of the Embryo and Fetus
El impacto de la exposición al metaboloma de esteroides materno-fetales en el crecimiento infantil y los resultados neurológicos (IGRO)
Project Code: PI21/01269
The role of seafood and nut consumption on human neurodevelopment from pregnancy to adolescence
ALTER - Contaminación del aire, microbiota intestinal y neurodesarrollo en los primeros 24 meses de vida
Project Code: PI21/01278
Urban and social environment and childhood obesity – a natural moving2health experiment
Infection acquisition in early life and health outcomes in childhood - MARATO TV3