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Chagas

TcONTROL

Antigen-specific immunological biomarkers associated to control of infection by T. cruzi.

Duration: 01/01/2017-31/15/2019
Coordinator: Manuel Carlos López (IPBLN)
Funded by: MINECO

Los objetivos principales son:

Determinar en pacientes crónicos de Chagas el impacto del tratamiento con benznidazol en el perfil inmunológico (fenotípico y funcional) de las poblaciones linfocitarias T. El estudio se centrará en aquellos marcadores que se encuentren modificados según el grado de severidad de la patología de Chagas.
Caracterizar en un modelo de infección natural las modificaciones inducidas por el embarazo en el perfil inmunológico de linfocitos T CD4+ y CD8+, a nivel funcional y de expresión de receptores inhibitorios.
Analizar, utilizando un modelo murino de infección experimental, la respuesta inmunológica de células T (CD4 y CD8) potencialmente asociada al control de la infección por T. cruzi.

Financiación total:

121.000 €

ISGlobal team

Joaquim Gascon Brustenga
Maria Jesús Pinazo Delgado

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Financiación total:

Our Team

ISGlobal team

Other projects

See all related projects

Cookies and privacy

Type of cookies used on the Website

First-party cookies

Third-party analytics cookies

Consent

Disabling and blocking cookies

Withdrawing your consent

Changing your browser's cookie configuration and settings

Internet Explorer:

Safari (and for iOS)

Changes to the Cookies Policy

Contact