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El impacto de la exposición al metaboloma de esteroides materno-fetales en el crecimiento infantil y los resultados neurológicos (IGRO)

Project Code: PI21/01269

Photo: Pexels / Pixabay

Duration: 01/01/2022 - 31/12/2024
Coordinator: Martine Vrijheid
Funded by: Instituto de Salud Carlos III. Este proyecto está cofinanciado por el Fondo Europeo de Desarrollo Regional (FEDER). “Una manera de hacer Europa”

La importancia fisiológica de las hormonas esteroides durante el embarazo es bien conocida. Sin embargo, su papel crucial neuroprotector y su impacto a largo plazo no se ha estudiado en las personas.

El objetivo principal es evaluar los efectos de la exposición prenatal al metaboloma de esteroides sobre el desarrollo neurológico y el crecimiento, desde el final del embarazo hasta los 14-16 años de edad.

Primero caracterizaremos este perfil único de esteroides en 1.200 mujeres embarazadas de dos cohortes longitudinales materno-infantiles establecidas en España. Se cuantificarán más de 70 metabolitos de hormonas esteroideas (incluyendo progestágenos, andrógenos, estrógenos y corticosteroides) en muestras de orina ya recolectadas y se describirá la variabilidad interindividual.

El metaboloma de esteroides se asociará con datos ya recopilados sobre el crecimiento fetal e infantil y el desarrollo del cerebro hasta los 2 años en una cohorte de descubrimiento (BiSC, N = 700) y se validará en una cohorte independiente (INMA-SAB, N = 500).

Un segundo objetivo es evaluar el efecto a largo plazo de estas "huellas" de esteroides en las trayectorias de crecimiento, la obesidad y los resultados conductuales hasta los 14-16 años de edad.

Finalmente, estableceremos y cuantificaremos el papel mediador de las firmas metabólicas maternas en la asociación entre sustancias químicas toxicas y el crecimiento y el neurodesarrollo fetal.

Este será el primer estudio longitudinal en humanos que evaluará el papel y el efecto del metaboloma de esteroides en el crecimiento y desarrollo neuronal. Este enfoque puede ser eficaz para predecir trastornos multifactoriales y en el diagnóstico temprano y la prevención de patologías fetales e infantiles.

Financiación total

100.000 €

Coordinadora

Martine Vrijheid Research Professor and Head of the Environment and Health over the Lifecourse Programme

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Financiación total

Our Team

Coordinadora

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Cookies and privacy

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Consent

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Changes to the Cookies Policy

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