Investigación Programas
Investigación

Identificación de QTLs moleculares y sus interacciones con factores ambientales (GXE) en población infantil

Duración
2018-2020
Coordinador
Mariona Bustamante (ISGlobal)
Financiadores
Instituto de Salud Juan Carlos III, Unión Europea

Genetic variants, environmental exposures and their interactions (GxE) influence complex phenotypes in humans. However, they are difficult to identify. Molecular endophenotypes (ie. DNA methylation levels), which are more specific and can be measured with less error, might facilitate the identification of these determinants.

The objective of this project is the identification of genetic polymorphisms associated with molecular endophenotypes (molecular QTLs - quantitative trait loci) in children, and to evaluate their interaction with environmental factors (GxE).

The project is built on existing data of 1300 European children from HELIX (The Human Early-Life Exposome), consisting of prenatal and postnatal exposures (>200 variables) and molecular endophenotypes measured at the age of 7-9 years (methylation, transcriptomics, metabolomics, and proteomics). As part of this proposal, HELIX children will be genome-wide genotyped (GWAS), and loci associated with molecular endophenotypes levels (QTL) and variability (var-QTL) will be identified using multivariate linear regressions. The GxE interactions will be based on a priori hipothesis derived from the var-QTLs analysis or from studies of GxE in in vitro models.

The dissection at molecular level proposed in this project will help to elucidate the causes and mechanisms of complex diseases.

Budget

108.900,00 euros

Este proyecto está cofinanciado por el Fondo Europeo de Desarrollo Regional (FEDER). “Una manera de hacer Europa”

 

Nuestro equipo

Principal Investigator (PI)

Otros proyectos

Ver proyectos pasados

EGG/EAGLE

Early Genetics Growth/Early Genetics and Lifecourse Epidemiology

PACE

Pregnancy and Childhood Epigenetics

APACHE

Air Pollution, Autism spectrum disorders, and brain imaging in CHildren amongst Europe

LIFECYCLE

Early-life stressors and LifeCycle health

ATHLETE

Advancing Tools for Human Early Lifecourse Exposome Research and Translation

MOOD-COVID

Pre- and post-natal Maternal mental health and newbOrn neurOdevelopment during the COVID-19 panDemic

EUCAN-Connect

A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health

OBERON

An integrative strategy of testing systems for identification of EDs related to metabolic disorders

The Lungfit Project

Socioeconomic Status, Physical Activity, and Respiratory Health in Pregnant Women, Children, and Adolescents

ExPEC-TEEN

Prenatal Exposure to Environmental Pollutants and Metabolic and Cardiovascular Health of the Teenagers

AURORA 2021

Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics

HELIX-NAFLD

Developmental origins of child liver injury: the effect of early life environmental exposures

UrbaMet

Entorno Urbano y Salud Cardiometabólica desde el Nacimiento hasta la Adolescencia

NutriPROGRAM

Early-life Nutritional Programming of Metabolic Health through Epigenetic Pathways

ELHNA

Exposures to light pollution and heat, and neurodevelopment in adolescents

ONES

Fine Particle Matter, Fetal Growth, and Neurodevelopment: Examining Critical Windows of Susceptibility

AIR-NB

Pre-natal exposure to urban AIR pollution and pre- and post-Natal Brain development

FRONTIER

Traffic-Related Air Pollution and Birth Weight: the Roles of Noise, Placental Function, Green Space, Physical Activity, and Socioeconomic Status

The APBO Project

Air Pollution and Birth Outcomes: Windows of Exposure and Health and Economic Impact Assessment

INMA-Ado-Sueño

Radio Frequency Electromagnetic Fields, Noise, and Sleep Disorders in Adolescence

ANSES HyPAXE

Prenatal Exposure to a Family of Short Half-Life Endocrine Disruptors, Dysregulation of the Hypothalamic–Pituitary–Adrenal Axis and Potential Implication for Child Neurodevelopment at Early Age

EXPO-ENFANTS

Caractérisation des usages et de l’exposition aux radiofréquences induite par les dispositifs de communication mobiles chez les enfants

Lily

Light at Night Exposure and Sleep Quality

EMBRYORAD

Radiofrequency Electromagnetic Fields, Other Environmental Factors, and Development of the Embryo and Fetus

IGRO

The Impact of Maternal-Fetal Steroid Metabolome Exposure on Child GROwth and Neurological Outcomes

NutinBrain

The role of seafood and nut consumption on human neurodevelopment from pregnancy to adolescence

ALTER

Air Pollution, Gut Microbiota and Neurodevelopment in the First 24 Months of Life

UrbanKids

Urban and social environment and childhood obesity – a natural moving2health experiment