Publicador de contenidos

Investigación

ExPEC-TEEN

Prenatal Exposure to Environmental Pollutants and Metabolic and Cardiovascular Health of the Teenagers

Proyecto ExPEC-TEEN
Foto: Gaelle Marcel / Unsplash
Duración
13/11/2019 - 13/07/2023
Coordinador
Charline Warembourg
Financiadores
ANSES (Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail, France)

Aim

The general objective of ExPEC-TEEN is to study the effect of early-life exposure to environmental contaminants, especially chemicals with endocrine-disrupting activities (EDCs), on metabolic and cardiovascular outcomes in adolescents.

Challenges

ExPEC-TEEN will go beyond the limitations of previous studies and fill the current gaps by:

  • improving the phenotype characterization;
  • following children longitudinally from in utero life period until adolescence; and
  • taking into account a wide range of EDCs during pregnancy.

Methods

The program of ExPEC-TEEN aims at conducting a new and harmonized follow-up of the participants enrolled in the PELAGIE (France) and INMA-Sabadell (Spain) cohorts, at the teen ages.

The protocol will include a clinical examination of the child at 15-17 years for anthropometric and cardiovascular measurements, and a fasting blood sample collection. More specifically, metabolic health of the adolescent will be assessed by anthropometric measures and biological markers of dyslipidaemia, insulin resistance, and transaminases, and cardiovascular health will be assessed using a classical measure of blood pressure and novel markers characterizing arterial stiffness and microcirculation through the measure of the pulse wave velocity and the diameter of the retinal vessels.

Advanced statistical methods will be used to evaluate the simultaneous effect of prenatal exposure to a wide range of chemicals.

Impact

Benefiting from the longitudinal collection of health and environmental data from the perinatal period in the PELAGIE and INMA-Sabadell cohorts, the project will provide important findings for public health with potential recommendations for health promotion and for disease prevention strategies.

A more exhaustive evaluation of cardiometabolic outcomes in adolescence would allow a better understanding of the early age processes most affected by environmental factors. Furthermore, the study of a wide range of chemicals would improve knowledge on the health effects of low-dose and mixture of exposure to EDCs.

Funding

Total: 199,864 €

ISGlobal: 67,447 €

Nuestro equipo

Coordinator

ISGlobal Team

Otros proyectos

Ver proyectos pasados

MCC-Spain

Estudio multi-caso control poblacional, incluyendo tumores de alta incidencia en España

HELIX

Novel tools for integrating early-life environmental exposures and child health across Europe

EGG/EAGLE

Early Genetics Growth/Early Genetics and Lifecourse Epidemiology

PACE

Pregnancy and Childhood Epigenetics

LIFECYCLE

Early-life stressors and LifeCycle health

OMEGA-NET

Network on the Coordination and Harmonisation of European Occupational Cohorts

HARMONIC

Health effects of cArdiac fluoRoscopy and mOdern radIotherapy in paediatriCs

Mobilise-D

Connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement

EARLY-ADAPT

Signs of Early Adaptation to Climate Change

COVICAT

Cohorte Covid-19 en Cataluña

ATHLETE

Advancing Tools for Human Early Lifecourse Exposome Research and Translation

CONTENT

Cohorte de COVID-19 en España: dinámica social, salud mental y desigualdades

EUCAN-Connect

A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health

OBERON

An integrative strategy of testing systems for identification of EDs related to metabolic disorders

EXPANSE

EXposome Powered tools for healthy living in urbAN SEttings

AURORA 2021

Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics

ONES

Fine Particle Matter, Fetal Growth, and Neurodevelopment: Examining Critical Windows of Susceptibility

AIR-NB

Pre-natal exposure to urban AIR pollution and pre- and post-Natal Brain development

NutinBrain

The role of seafood and nut consumption on human neurodevelopment from pregnancy to adolescence

UrbanKids

Urban and social environment and childhood obesity – a natural moving2health experiment

iGenCO

In-Depth Genomics and Cross-Omics Analysis for Undiagnosed Rare Diseases on a User-Friendly Collaborative Platform

CityExposomeCat

An Exposome Approach to Urban Health: Individualized Environmental Exposure Assessment in an Adults Population Cohort Study (GCAT)

TwinAir

Digital Twins Enabled Indoor Air Quality Management for Healthy Living

UBDPOLICY

The Urban Burden of Disease Estimation for POLICY Making

TOLIFE

Combining Artificial Intelligence and smart sensing TOward better management and improved quality of LIFE in chronic obstructive pulmonary disease

BWater

Drinking Water in Barcelona: Sustainability and Health Impact Assessment

INTERCAMBIO

Interventions to promote mental and physical health in changing working environments due to climate change, sustainable work practices, and in green jobs

intoDBP

Innovative Tools to Control Organic Matter and Disinfection Byproducts in Drinking Water

FINDOOR

FTIR spectroscopy for real-time detection of bacterial outbreaks and the rapid identification of pathogenic serotypes, relapsing infections and antibiotic resistance

OccRF-Health

Occupational exposure to radiofrequency electromagnetic fields: From exposure assessment to study of health in workers and their offspring

EPHOR

Exposome Project for Health and Occupational Research

EXPONIT

Analysing and studying how night shift work affects workers' circadian rhythms and health