Lancet Infectious Diseases 2019; 19(12): 1312 - 1324

The global burden of non-typhoidal salmonella invasive disease: a systematic analysis for the Global Burden of Disease Study 2017.

GBD 2017 Non-Typhoidal Salmonella Invasive Disease Collaborators.
02.12.2019

BACKGROUND

Non-typhoidal salmonella invasive disease is a major cause of global morbidity and mortality. Malnourished children, those with recent malaria or sickle-cell anaemia, and adults with HIV infection are at particularly high risk of disease. We sought to estimate the burden of disease attributable to non-typhoidal salmonella invasive disease for the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017.

METHODS

We did a systematic review of scientific databases and grey literature, and estimated non-typhoidal salmonella invasive disease incidence and mortality for the years 1990 to 2017, by age, sex, and geographical location using DisMod-MR, a Bayesian meta-regression tool. We estimated case fatality by age, HIV status, and sociodemographic development. We also calculated the HIV-attributable fraction and estimated health gap metrics, including disability-adjusted life-years (DALYs).

FINDINGS

"We estimated that 535\xE2\x80\x88000 (95% uncertainty interval 409\xE2\x80\x88000-705\xE2\x80\x88000) cases of non-typhoidal salmonella invasive disease occurred in 2017, with the highest incidence in sub-Saharan Africa (34\xC2\xB75 [26\xC2\xB76-45\xC2\xB70] cases per 100\xE2\x80\x88000 person-years) and in children younger than 5 years (34\xC2\xB73 [23\xC2\xB72-54\xC2\xB77] cases per 100\xE2\x80\x88000 person-years). 77\xE2\x80\x88500 (46\xE2\x80\x88400-123\xE2\x80\x88000) deaths were estimated in 2017, of which 18\xE2\x80\x88400 (12\xE2\x80\x88000-27\xE2\x80\x88700) were attributable to HIV. The remaining 59\xE2\x80\x88100 (33\xE2\x80\x88300-98\xE2\x80\x88100) deaths not attributable to HIV accounted for 4\xC2\xB726 million (2\xC2\xB738-7\xC2\xB738) DALYs in 2017. Mean all-age case fatality was 14\xC2\xB75% (9\xC2\xB72-21\xC2\xB71), with higher estimates among children younger than 5 years (13\xC2\xB75% [8\xC2\xB74-19\xC2\xB78]) and elderly people (51\xC2\xB72% [30\xC2\xB72-72\xC2\xB79] among those aged \xE2\x89\xA570 years), people with HIV infection (41\xC2\xB78% [30\xC2\xB70-54\xC2\xB70]), and in areas of low sociodemographic development (eg, 15\xC2\xB78% [10\xC2\xB70-22\xC2\xB79] in sub-Saharan Africa)."

INTERPRETATION

We present the first global estimates of non-typhoidal salmonella invasive disease that have been produced as part of GBD 2017. Given the high disease burden, particularly in children, elderly people, and people with HIV infection, investigating the sources and transmission pathways of non-typhoidal salmonella invasive disease is crucial to implement effective preventive and control measures.

FUNDING

Bill & Melinda Gates Foundation.
DOI
10.1016/S1473-3099(19)30418-9