Environmental Research 2020;: 110422 -

Profile of exposures and lung function in adults with asthma: an exposome approach in the EGEA study.

Guillien A, Lepeule J, Seyve E, Le Moual N, Pin I, Degano B, Garcia-Aymerich J, Pépin JL, Pison C, Dumas O, Varraso R, Siroux V
05.11.2020

BACKGROUND

Environmental research on multifactorial health outcomes calls for exposome approaches able to assess the joint effect of multiple exposures.

OBJECTIVE

Our aim was to identify profiles of exposure to lifestyle/environmental factors associated with lung function in adults with asthma using a cluster-based approach.

METHODS

sub: - "1" - "1" content: - "We used data from 599 adults of the Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy (EGEA) (mean age 39.0 years, 52% men) who ever had asthma. Exposures to 53 lifestyle/environmental factors were assessed by questionnaires or geographic information systems-based models. A two-step approach was developed: 1) exposome dimension reduction by selecting factors showing association with forced expiratory volume in 1 second (FEV" - ) (p<0.20) in an exposome-wide association study (ExWAS), 2) clustering analysis using the supervised Bayesian Profile Regression (sBPR) to group individuals according to FEV - " level and to their profile of exposure to a reduced set of uncorrelated exposures (each paired correlation<0.70) identified in step 1."

RESULTS

sub: - "1" - "1" content: - The ExWAS identified 21 factors showing suggestive association with FEV - " (none significant when controlling for multiple tests). The sBPR conducted on 15 uncorrelated exposures identified in step 1, revealed 3 clusters composed of 30, 115 and 454 individuals with a mean\xC2\xB1SD FEV" - "(%pred) of 79%\xC2\xB121, 90%\xC2\xB119 and 93%\xC2\xB116, respectively. Cluster 1 was composed of individuals with heavy smoking, poor diet, higher outdoor humidity and proximity to traffic, while cluster 2 and 3 included individuals with moderate/low levels of exposure to these factors."

DISCUSSION

sub: - "1" content: - This exposome study identified a specific profile of joint lifestyle and environmental factors, associated with a low FEV - " in adults with asthma. None of the exposures revealed significant association when considered independently."
DOI
10.1016/j.envres.2020.110422