DescripciónThe Barcelona Institute for Global Health (ISGlobal) is a cutting-edge institute addressing global public health challenges through research, translation into policy and education. ISGlobal has a broad portfolio in communicable and non-communicable diseases including environmental and climate determinants, and applies a multidisciplinary scientific approach ranging from the molecular to the population level. Research is organized in three main areas, Malaria and other Infectious Diseases, Child and Maternal Health, and Urban Health, Climate & Non-Communicable Diseases. ISGlobal is accredited with the Severo Ochoa distinction, a seal of excellence of the Spanish Science Ministry.
What We Are Looking for
About the project:
Plasmodium falciparum is responsible for the most severe forms of human malaria. Transcriptional regulation plays a key role in malaria parasite biology, as it controls fundamental processes such as life cycle progression, developmental “decisions”, antigenic variation and adaptation to the conditions of the environment. Some of these processes are regulated at the epigenetic level, with a key role for euchromatin-heterochromatin transitions.
We are recruiting a postdoctoral scientist to work in a project with title “Transcriptional regulation of adaptation and developmental decisions in malaria parasites: from epigenetic variation to directed transcriptional responses”, funded by the Spanish Ministry of Science and Innovation (RETOS call). In this project we will investigate the epigenetic mechanisms underlying heterochromatin formation and their role in regulating clonal variation and adaptive processes in malaria, and also the transcriptional response of the parasite to heat shock. The project will involve the use of multiple techniques including genome editing with CRISPR-Cas9 technology, transcriptomics (RNA-seq/microarrays), epigenomics (ChIP-seq) and basic molecular and cellular parasitology.
- Biological sciences
Training and experience /Qualifications:
- A PhD in a discipline related with molecular and cellular biology
- High level of enthusiasm and motivation; passion for science!
- Previous expertise in malaria research and/or in epigenetics/chromatin biology is desirable but not essential
- Bioinformatics skills are desirable but not essential
- Experiments with P. falciparum cultures
- Molecular and cellular biology experiments
- Data analysis and preparation of manuscripts
- Present results in scientific conferences
- Contribute to scientific discussion and training of new members of the team
Skills (HR proposes for PhD student, serve as a reference)
- Capacity to work both independently and as part of a team
- Excellent written and oral communication skills in English
- Excellent organization and coordination skills
- Demonstrated track record of achievements
- Excellent written and oral communication skills in English are essential
How to apply:
The receipt of applications will be open until November 30th 2020 or until the position is covered
Applications will be accepted until 17.00 CET of the closing date.
Only shortlisted candidates will be contacted.
Informal enquiries can be addressed to Alfred Cortés (firstname.lastname@example.org)