International Journal of Infectious Diseases 2020

Persistent replication of SARS-CoV-2 in a severely immunocompromised treated with several courses of remdesivir.

Camprubí-Ferrer D, Gaya A, Marcos MÁ, Martí-Soler H, Soriano A, Mosquera MDM, Oliver A, Santos M, Muñoz J, Garcia-Vidal C
Microbiological response of SARS-CoV-2 to remdesivir in immunocompromised patients has not been evaluated. We present the case of a severely immunocompromised patient with persistent replication of SARS-CoV-2, who required different courses of remdesivir. Short courses of remdesivir might be insufficient in immunocompromised patients due to prolonged viral clearance. Copyright © 2020. Published by Elsevier Ltd.