- 01/05/2021 - 31/08/2024
- Clara Menéndez
- Funded by
- The European & Developing Countries Clinical Trials Partnership (EDCTP)
As efforts to control malaria are stalling, and the disease is particularly severe in children under the age of two, it is imperative for countries in sub-Saharan Africa, with areas of moderate-to-high transmission, to implement Intermittent Preventive Treatment in infants (IPTi) delivered through the Expanded Program on Immunization (EPI), which is the only feasible, sustainable and cost-effective strategy to reach this high-risk group. IPTi has been shown to be safe, efficacious in reducing clinical malaria, anaemia and hospital admissions, and to be highly cost-effective since it is delivered alongside EPI and uses an inexpensive antimalarial drug (Sulfadoxine-Pyrimethamine); for all these reasons, the World Health Organisation recommends it for malaria prevention in infants. However, IPTi has not been implemented to date, except in Sierra Leone.
MULTIPLY is a large-scale implementation development cooperation project, which includes public and private European and African institutions aiming at maximising the delivery and uptake of IPTi, to achieve full potential and effectiveness of this intervention.
Research partners from Mozambique, Sierra Leone and Togo in selected country districts will conduct the implementation of IPTi at health facilities and EPI mobile-outreach clinics using a paediatric dispersible formulation of SP, alongside routine vaccinations and vitamin A supplementation. Children will receive up to a maximum of 6 doses of IPTi in the first two years of life.
Through this implementation, capacity will be built and fundamental programmatic issues to achieving effectiveness will be assessed, including:
- IPTi operational feasibility and acceptability;
- impact on health services integration, i.e. on EPI immunisations and vitamin A administration coverage;
- the cost and cost-effectiveness of IPTi delivery including through the outreach EPI platform;
- the impact on malaria incidence, anaemia, overall mortality, SP resistance development and the safety of the intervention.
The integration of IPTi with EPI contacts, together with social and behaviour change communication campaigns to inform communities of the importance of EPI, and the malaria protection afforded by IPTi delivered at the EPI, could lead to an increased demand for EPI.
This project is part of the EDCTP2 programme supported by the European Union
- Clara Menéndez Research Professor, Director of the Maternal, Child and Reproductive Health Initiative and Programme
Other projectsSee Past Projects
The Malaria Eradication Scientific Alliance - MESA is dedicated to advancing the science of malaria eradication.
Study of immune correlates of protection against malaria after vaccination with RTS,S/AS01E: a comprehensive immunological arm of a Phase III double-blind, randomized, controlled multi-center trial
Mozambican Alliance Towards Elimination of Malaria
Pregnant women as a sentinel group for malaria surveillance in an era of changing malaria transmission
A path towards new diagnostic and prevention tools for severe infectious pathologies
Exploration of the singularities of the sugar nucleotide metabolism and description of novel glycosylation pathways in the malaria parasite
Investigating new aspects of the mechanisms and biological functions of epigenetic variation in malaria parasites
Mechanistic aspects of anemia and splenomegaly caused by plasmodium vivax, a neglected human parasite
Transforming IPT for optimal pregnancy
Development of nanovectors for the targeted delivery in Anopheles mosquitoes of agents blocking transmission of Plasmodium parasites
Broad One Health Endectocide-based Malaria Intervention in Africa
Unravelling Disease Tolerance and Host Resistance in Afebrile 'P. falciparum' Infections: a Prospective Study in Mozambican Adults
P. falciparum genomic intelligence in Mozambique
Malaria mass and focal drug administration to advance malaria elimination in Mozambique: accelerating programmatic implementation and policy translation
Enhanced and equitable coverage of COVID-19 testing and treatment in Bolivia and Paraguay
Continued validation of the minimally invasive autopsy for the investigation of the causes of death in infants, and establishment of a research and training center to study causes of death
Measuring community prevalence among HIV exposed children in rural Southern Mozambique
Improving Maternal and Infant Health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women
Improving Care through Azithromycin Research for Infants in Africa
Identification of Prematurity and Pre-Eclampsia as Causes of Mortality
Strengthening Epidemiological Surveillance in Benin and Burkina Faso for an Effective Response to COVID-19
Prevalence and impact of SARS-CoV-2 infection on maternal and infant health in African populations