LIFECYCLE

Early-life stressors and LifeCycle health

Duration
2017-2021
Coordinator
Vincent Jaddoe (Erasmus MC-University Medical Center de Rotterdam)
Funded by
European Comission - Horizon 2020

Early life is an important window of opportunity to improve health across the full lifecycle. European pregnancy and child cohort studies together offer a unique opportunity to identify a wide range of early life stressors linked with individual biological, developmental and health trajectory variations, and to the onset and evolution of noncommunicable diseases.

LifeCycle will establish the EU CHILD Cohort Network, which brings together existing, successful pregnancy and child cohorts and biobanks, by developing a governance structure taking account of national and European ethical, legal and societal implications, a shared data-management platform and data-harmonization strategies.

The project will enrich this EU CHILD Cohort Network by generating new integrated data on early life stressors related to socio-economic, migration, urban environment and life-style determinants, and will capitalize on these data by performing hypothesis-driven research on early life stressors influencing cardio-metabolic, respiratory and mental health trajectories during the full lifecycle, and the underlying epigenetic mechanisms. LifeCycle  will translate these results into recommendations for targeted strategies and personalized prediction models to improve health trajectories for current and future Europeans generations by optimizing their earliest phase of life.

To strengthen this long-term collaboration, LifeCycle will organize yearly international meetings open to pregnancy and child cohort researchers, introduce a Fellowship Training Programme for exchange of junior researchers between European pregnancy or child cohorts, and develop e-learning modules for researchers performing life-course health studies.

Ultimately, the project will lead to a unique sustainable EU CHILD Cohort Network, and provide recommendations for targeted prevention strategies by identification of novel markers of early life stressors related to health trajectories throughout the lifecycle.

This ambitious project combines data on over 250,000 children and their parents from Europe and Australia to provide robust scientific evidence on this important topic. Research findings will be translated into new prevention and intervention policies focused on the earliest phase of life, giving next generations the best possible start.

Partners

  • Erasmus Universitair Medisch Centrum Rotterdam, The Netherlands (Coordinator)
  • ISGlobal, Barcelona, Spain
  • University of Turin, Italy
  • University of Southampton, United Kingdom
  • University of Bristol, United Kingdom
  • University of Copenhagen, Denmark
  • Bradford Teaching Hospitals NHS Foundation Trust, United Kingdom
  • University Medical Center Groningen, The Netherlands
  • University of Crete, Greece
  • Norwegian Institute of Public Health, Oslo, Norway
  • French National Institute of Health and Medical Research (INSERM), Villejuif, France
  • University of Oulu, Finland
  • Samfundet Folkhälsan, Helsinki, Finland
  • Ludwig Maximilians University of Munich, Germany
  • VU University Amsterdam , The Netherlands
  • Concentris Research Management GmbH
  • University of Western Australia, Perth, Australia

 

Total funding

10,4 milions.

Our Team

Principal Investigators (PI)

  • Martine Vrijheid
    Martine Vrijheid Head of the Childhood and Environment Programme, Research Professor and Coordinator of INMA-Sabadell Cohort
  • Jordi Sunyer
    Jordi Sunyer Research Professor

ISGlobal Team

Other projects

See Past Projects

EGG/EAGLE

Early Genetics Growth/Early Genetics and Lifecourse Epidemiology

PACE

Pregnancy and Childhood Epigenetics

APACHE

Air Pollution, Autism spectrum disorders, and brain imaging in CHildren amongst Europe

ATHLETE

Advancing Tools for Human Early Lifecourse Exposome Research and Translation

MOOD-COVID

Pre- and post-natal Maternal mental health and newbOrn neurOdevelopment during the COVID-19 panDemic

EUCAN-Connect

A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health

OBERON

An integrative strategy of testing systems for identification of EDs related to metabolic disorders

The Lungfit Project

Socioeconomic Status, Physical Activity, and Respiratory Health in Pregnant Women, Children, and Adolescents

ExPEC-TEEN

Prenatal Exposure to Environmental Pollutants and Metabolic and Cardiovascular Health of the Teenagers

AURORA 2021

Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics

HELIX-NAFLD

Developmental origins of child liver injury: the effect of early life environmental exposures

UrbaMet

Entorno Urbano y Salud Cardiometabólica desde el Nacimiento hasta la Adolescencia

NutriPROGRAM

Early-life Nutritional Programming of Metabolic Health through Epigenetic Pathways

ELHNA

Exposures to light pollution and heat, and neurodevelopment in adolescents

ONES

Fine Particle Matter, Fetal Growth, and Neurodevelopment: Examining Critical Windows of Susceptibility

AIR-NB

Pre-natal exposure to urban AIR pollution and pre- and post-Natal Brain development

FRONTIER

Traffic-Related Air Pollution and Birth Weight: the Roles of Noise, Placental Function, Green Space, Physical Activity, and Socioeconomic Status

The APBO Project

Air Pollution and Birth Outcomes: Windows of Exposure and Health and Economic Impact Assessment

INMA-Ado-Sueño

Radio Frequency Electromagnetic Fields, Noise, and Sleep Disorders in Adolescence

ANSES HyPAXE

Prenatal Exposure to a Family of Short Half-Life Endocrine Disruptors, Dysregulation of the Hypothalamic–Pituitary–Adrenal Axis and Potential Implication for Child Neurodevelopment at Early Age

EXPO-ENFANTS

Caractérisation des usages et de l’exposition aux radiofréquences induite par les dispositifs de communication mobiles chez les enfants

Lily

Light at Night Exposure and Sleep Quality

EMBRYORAD

Radiofrequency Electromagnetic Fields, Other Environmental Factors, and Development of the Embryo and Fetus

IGRO

The Impact of Maternal-Fetal Steroid Metabolome Exposure on Child GROwth and Neurological Outcomes

NutinBrain

The role of seafood and nut consumption on human neurodevelopment from pregnancy to adolescence