Asset Publisher

Research & Innovation Programmes
Research

ANSES HyPAXE

Prenatal Exposure to a Family of Short Half-Life Endocrine Disruptors, Dysregulation of the Hypothalamic–Pituitary–Adrenal Axis and Potential Implication for Child Neurodevelopment at Early Age

ANSES HyPAXE Project
Duration
13/11/2019 - 12/05/2023
Coordinator
Jordi Sunyer
Funded by
ANSES - Agence Nationale de Sécurité Sanitaire de l'Alimentation, de l'Environnement et du Travail

This project is in line with the Developmental Origins of Health and Diseases (DOHaD) hypothesis suggesting that exposure to adverse environmental conditions during early life can affect short but also long term health outcomes. In the HyPAxE project, we hypothesize that exposure to short halflife endocrine disruptors during pregnancy can induce dysregulation of the I-IPA axis during critical periods of brain development which, in turn, could lead to neurodevelopmental disorders later in life.

Objectives

The HyPAxE project aims to:

  • test whether prenatal exposure to a family of endocrine disruptors (phenols) is associated with child neurodevelopment (including cognition, motricity and dysregulated behaviour);
  • explore the associations between exposure to phenols and dysregulation of the hypothalamic-pituitary-adrenal (I-IPA) axis functioning;
  • characterize the contribution of dysregulation of the I-IPA axis functioning in the associations of phenols and child neurodevelopment.


Figure 3: Aims of the HyPAxE project

Total Funding

32.490 €

Our Team

Coordinator

ISGlobal Team

  • Payam Dadvand
    Payam Dadvand
  • Martine Vrijheid
    Martine Vrijheid Research Professor and Head of the Environment and Health over the Lifecourse Programme

Other projects

See Past Projects

MCC-Spain

Population based multicasecontrol study on common tumours in Spain

HELIX

Novel tools for integrating early-life environmental exposures and child health across Europe

EGG/EAGLE

Early Genetics Growth/Early Genetics and Lifecourse Epidemiology

PACE

Pregnancy and Childhood Epigenetics

LIFECYCLE

Early-life stressors and LifeCycle health

OMEGA-NET

Network on the Coordination and Harmonisation of European Occupational Cohorts

HARMONIC

Health effects of cArdiac fluoRoscopy and mOdern radIotherapy in paediatriCs

Mobilise-D

Connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement

EARLY-ADAPT

Signs of Early Adaptation to Climate Change

COVICAT

Cohorte Covid-19 en Cataluña

ATHLETE

Advancing Tools for Human Early Lifecourse Exposome Research and Translation

CONTENT

Cohort of COVID-19 in Spain: social dynamics, mental health and inequalities

EUCAN-Connect

A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health

OBERON

An integrative strategy of testing systems for identification of EDs related to metabolic disorders

EXPANSE

EXposome Powered tools for healthy living in urbAN SEttings

AURORA 2021

Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics

ONES

Fine Particle Matter, Fetal Growth, and Neurodevelopment: Examining Critical Windows of Susceptibility

AIR-NB

Pre-natal exposure to urban AIR pollution and pre- and post-Natal Brain development

NutinBrain

The role of seafood and nut consumption on human neurodevelopment from pregnancy to adolescence

UrbanKids

Urban and social environment and childhood obesity – a natural moving2health experiment

iGenCO

In-Depth Genomics and Cross-Omics Analysis for Undiagnosed Rare Diseases on a User-Friendly Collaborative Platform

CityExposomeCat

An Exposome Approach to Urban Health: Individualized Environmental Exposure Assessment in an Adults Population Cohort Study (GCAT)

TwinAir

Digital Twins Enabled Indoor Air Quality Management for Healthy Living

UBDPOLICY

The Urban Burden of Disease Estimation for POLICY Making

TOLIFE

Combining Artificial Intelligence and smart sensing TOward better management and improved quality of LIFE in chronic obstructive pulmonary disease

BWater

Drinking Water in Barcelona: Sustainability and Health Impact Assessment

INTERCAMBIO

Interventions to promote mental and physical health in changing working environments due to climate change, sustainable work practices, and in green jobs

intoDBP

Innovative Tools to Control Organic Matter and Disinfection Byproducts in Drinking Water

FINDOOR

FTIR spectroscopy for real-time detection of bacterial outbreaks and the rapid identification of pathogenic serotypes, relapsing infections and antibiotic resistance

OccRF-Health

Occupational exposure to radiofrequency electromagnetic fields: From exposure assessment to study of health in workers and their offspring

EPHOR

Exposome Project for Health and Occupational Research

EXPONIT

Analysing and studying how night shift work affects workers' circadian rhythms and health