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Chagas

TcONTROL

Antigen-specific immunological biomarkers associated to control of infection by T. cruzi.

Duration: 01/01/2017-31/15/2019
Coordinator: Manuel Carlos López (IPBLN)
Funded by: MINECO

Los objetivos principales son:

Determinar en pacientes crónicos de Chagas el impacto del tratamiento con benznidazol en el perfil inmunológico (fenotípico y funcional) de las poblaciones linfocitarias T. El estudio se centrará en aquellos marcadores que se encuentren modificados según el grado de severidad de la patología de Chagas.
Caracterizar en un modelo de infección natural las modificaciones inducidas por el embarazo en el perfil inmunológico de linfocitos T CD4+ y CD8+, a nivel funcional y de expresión de receptores inhibitorios.
Analizar, utilizando un modelo murino de infección experimental, la respuesta inmunológica de células T (CD4 y CD8) potencialmente asociada al control de la infección por T. cruzi.

Financiación total:

121.000 €

ISGlobal team

Joaquim Gascon Brustenga
Maria Jesús Pinazo Delgado

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VivaxEVTalk

Extracellular Vesicles as Intercellular Communicators and Biomarkers of Cryptic Erythrocytic Infections in Plasmodium vivax malaria

VaMonoS

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Financiación total:

Our Team

ISGlobal team

Other projects

Cookies and privacy

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