- 09/2017 - 08/2019
- Denise Naniche
- Funded by
- PEPFAR, Centers for Disease Control and Prevention
Mozambique’s national prevention of mother to child transmission of HIV (PMTCT) program was established in 2002 and rapidly expanded. In June 2013, the Ministry of Health launched WHO Option B+, which offers antiretroviral treatment for life to all HIV positive pregnant women. By the end of 2014, 742 health units were offering B+ out of 1272 health facilities offering PMTCT services.
In light of these efforts, Mozambique has achieved a rapid reduction in new child HIV infections, from 27,000 in 2009 to 12,000 in 2013. UNAIDS estimates that the country’s MTCT rate has decreased from 26% in 2009 to 12% in 2013. However, reliable measures of final MTCT rates after breastfeeding cessation are not available. Obtaining this information is challenging due to low retention in the PMTCT cascade. Also, though prolonged breastfeeding is common in Mozambique, we have no reliable information on duration of breastfeeding among HIV-exposed infants and children.
In order to begin assessing the impact of PMTCT efforts to date and obtain baseline information for further improvement of PMTCT programs, a programmatic evaluation to measure community HIV prevalence among HIV-exposed children after cessation of breastfeeding is urgently needed in Mozambique.
The main objective of the METRO study is to estimate the prevalence of HIV in exposed children under 4 years of age in the community, after cessation of breastfeeding, in Southern rural Mozambique in the period between 2012 and 2016.
More specifically, the project aims:
- To describe characteristics linked with child HIV exposure and HIV vertical transmission
- To estimate the duration of breastfeeding in the population of Manhiça district and to describe demographic, health, economic, and socio-cultural, characteristics of breastfeeding women
- To estimate mortality among HIV-positive mothers and HIV-exposed children
The project takes place within a demographic surveillance platform in Manhiça and offers testing and counseling to women and their children, identifying children exposed to HIV 48 months or younger.
The results obtained from this study will provide baseline data at subnational level that can later be used to estimate trends; and also used to initiate the elimination of mother-to-child transmission (EMTCT) pre-validation process according to WHO criteria. Furthermore it will be used to inform planning of national PMTCT program activities including potential community outreach programs, among other applications.
Other projectsSee Past Projects
Continued validation of the minimally invasive autopsy for the investigation of the causes of death in infants, and establishment of a research and training center to study causes of death
Contributing to the road map of maternal immunization: Determining the burden of Bordetella pertussis, respiratory syncytial virus (RSV) and Influenza virus in pregnant women and their infants in Mozambique
Surveillance of Zika virus infection in pregnant women travelling from affected areas
Transforming IPT for optimal pregnancyhttps://www.tiptopmalaria.org
Improving Maternal and Infant Health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women
Valor de la detección del ARNM de los biomarcadores CDKN2A, MKI67, TOP2A en el diagnóstico precoz de cáncer en hombres que tienen sexo con hombres VIH positivos
Infección por virus Zika en mujeres embarazadas que han viajado a zonas afectadas y evaluación de impacto en salud infantil
Scaling up HIV Counseling & Testing Services within a Health Demographic Surveillance System in Manhiça, Mozambique
Linkage and retention in care following home-based HIV testing serosurveys in Manhiça District, Southern Mozambique
Improved case detection through TB contact risk stratification by Xpert results and spatial parameters in Mozambique
Evaluation of the effect of weekly high dose rifapentine and isoniazid (3HP) vs periodic 3HP vs 6H for preventing TB among HIV-positive individualshttps://clinicaltrials.gov/ct2/show/NCT02980016
Optimizing provider-initiated HIV testing, linkage, and retention in care in the district of Manhiça, Mozambique