HIV/AIDS and Tuberculosis (TB)

At the end of 2014, there were some 37 million people in the world infected with HIV and almost one-third of the estimated 1.2 million deaths annually in this population were due to TB. In the same year, TB not associated with HIV caused a million deaths, making both diseases leading causes of global mortality. 

Efforts to strengthen HIV/TB interventions since 2000 have reduced the number of people dying of HIV-associated tuberculosis by 22%.  However, the low coverage of antiretroviral therapy, resistance to those drugs, and the lack of diagnosis of both infections continue to be a problem in sub-Saharan Africa, the area with the highest TB burden in the world where more than 70% of the people with HIV live. Access to antiretroviral therapy is a priority in the fight against both infections, and the aim of the UNAIDS 90-90-90 initiative is to diagnose 90% of cases of HIV infection, treat 90% of those infected, and achieve viral suppression in 90% of those receiving antiretroviral treatment by 2020. Reaching this goal would make it possible to eliminate HIV/AIDS by 2030.  

Our research on HIV/AIDS and TB focuses on the specific problems related to the epidemic in sub-Saharan Africa, where the incidence of both diseases is extremely high in adults and children.

Main Lines of Research

  • HIV and women's and children's health
  • Pathogenesis of the acute and early stages of HIV infection
  • Epidemiological and operational research in the community to improve access to antiretroviral therapy
  • Epidemiological studies to determine the burden of tuberculosis in the community
  • Assessment of new tools for the diagnosis, treatment and prevention of tuberculosis

Our Team


  • Denise Naniche
    Denise Naniche Research Professor, Co-Chair of the Viral and Bacterial Infections Programme

ISGlobal Team

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Highlighted Projects


Linkage and retention in care following home-based HIV testing serosurveys in Manhiça District, Southern Mozambique

Other projects

See Past Projects


Measuring community prevalence among HIV exposed children in rural Southern Mozambique