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Research, Malaria Elimination

Extracellular Vesicles in the Regulation of Host-Pathogen Interactions During Malaria

Photo: © NCBI
Date
16/05/2017
Hour
10.00 h
Place
Aula 17, Facultat de Medicina i Ciències de la Salut (Campus Clínic)
(Casanova, 143) Barcelona
Speaker
Pierre-Yves Mantel (University of Fribourg)

Intracellular and extracellular protozoan parasites, including those responsible for major human diseases such as malaria, secrete extracellular vesicles (EVs) to promote growth and induce transmission to evade the host immune system and to manipulate the microenvironment. In this open seminar, Pierre-Yves Mantel, Research Fellow at University of Fribourg (Switzerland), will discuss on the role of extracellular vesicle in regulation of host-pathogen interactions during malaria.

Pierre-Yves Mantel is investigating the host-parasite interaction during infections with Plasmodium falciparum, the causative agent of malaria. His research focuses on the role of EVs that are released by infected cells. EVs mediate cellular communication between parasites by regulating the transmission to the mosquito. Furthermore EVs modulate immune cell responses targeted to the parasites. EVs provide ways to understand the pathogenesis and will deliver new tools to fight this disease.