The Barcelona Institute for Global Health (ISGlobal) is a cutting-edge institute addressing global public health challenges through research, translation into policy and education. ISGlobal has a broad portfolio in communicable and non-communicable diseases including environmental and climate determinants, and applies a multidisciplinary scientific approach ranging from the molecular to the population level. Research is organized in three main areas, Malaria and other Infectious Diseases, Child and Maternal Health, and Urban Health, Climate & Non-Communicable Diseases. ISGlobal is accredited with the Severo Ochoa distinction, a seal of excellence of the Spanish Science Ministry.
What We Are Looking for
ISGlobal is seeking a lab technician who is interested on working in a research project of the team focused on heterochromatin biology in the malaria parasite Plasmodium falciparum.
The ISGlobal Malaria Epigenetics lab directed by ICREA Research Professor Alfred Cortés investigates the regulation of gene expression in the malaria parasite Plasmodium falciparum. We use a combination of approaches that include phenotypic characterization of parasites, molecular biology, multi-omics approaches, and genome editing with CRISPR-Cas9 technology. Our ultimate goal is to generate high-quality basic knowledge that is relevant for the fight against malaria. We try to solve problems from innovative perspectives.
About the project:
Plasmodium falciparum is responsible for the most severe forms of human malaria. Transcriptional regulation plays a key role in malaria parasite biology, as it controls fundamental processes such as life cycle progression, antigenic variation and adaptation to the conditions of the environment. Some of these processes are regulated at the epigenetic level, with a key role for euchromatin-heterochromatin transitions.
We are recruiting a lab technician to work in a project investigating heterochromatin formation and maintenance in P. falciparum. The project will involve the use of multiple techniques including genome editing with CRISPR-Cas9 technology, transcriptomics (RNA-seq/microarrays), epigenomics (ChIP-seq) and basic molecular and cellular parasitology.
- Biological Sciences
Training and experience /Qualifications
- BSc and MSc in a discipline related with molecular and cellular biology
- High level of enthusiasm and motivation; passion for science!
- Previous expertise in malaria research
- Previous expertise in epigenetics/chromatin biology, including ChIP-qPCR
- Ability to work closely with other members of the team on a highly collaborative environment
The main tasks will be to design and perform the experiments for a project focused on Plasmodium falciparum heterochromatin, in collaboration with other members of the team. Good integration in the team environment is essential.
- Experiments with P. falciparum cultures, including generation of transgenic parasite lines
- Molecular and cellular biology experiments
- chromatin analysis using ChIP-qPCR and ChIP-seq
- Contribute to scientific discussion and training of new members of the team
- Excellent written and oral communication skills in English are essential
- Duration: initially 4 months . There may be a possibility to extend the contract depending on availability of funds.
- Starting date: October or November 2022
- Contract: Full time
- Salary Range: According to ISGlobal salary scales, will depend on the level of experience and qualifications.
How to apply
Applicants must fill in the request form and include the following code reference position: Technician_MalariaEpigenetics_Oct22, attach the CV and a Cover Letter. Each attached document must be named with the candidate name and surname.
The receipt of applications will be open until the position is covered
Only the applications submitted through the request form will be considered.
Only shortlisted candidates will be contacted.
The interviews could be placed during the reception candidatures period.