Approximately 25 million pregnant women exposed yearly to malaria live in areas where Plasmodium vivax is endemic. While the effects of falciparum malaria in pregnancy have been well characterised and are responsible for considerable maternal and infant morbidity and mortality, surprisingly little is known about the impact of P. vivax infection during gestation.
Malaria in pregnancy was prioritised by the 7th Framework Program of the European Commission. To fill the knowledge gaps of vivax malaria in pregnancy, the PregVax study carried out a cohort observational study in pregnant women in five P. vivax endemic countries, Brazil, Colombia, Guatemala, India, and Papua New Guinea, broadly representing most of the world's P. vivax infections.
Around ten thousand pregnant women were enrolled by the five sites in total at the time of routine antenatal care visits and followed-up at the health facility until delivery.
The main objective of the PregVax study is to describe the epidemiological and clinical features of P. vivax malaria in pregnancy. The PregVax study will also determine if there are pregnancy-specific immune responses and characterize, genotypically and phenotypically, parasites of the placenta.
Pregvax is a project of The Clinic Foundation.
It belongs to the Malaria in Pregnancy Consortium.
- Clara Menéndez Research Professor, Director of the Maternal, Child and Reproductive Health Initiative and Programme
- Azucena BardajÍ Assistant Research Professor
- Carlota Dobaño Research Professor
- Alfredo Mayor Associate Research Professor
- Jaume Ordi Research Professor
- Mireia Piqueras Project Manager
- Hernando Del Portillo ICREA Research Professor
- Sergi Sanz Head of Department - Statistics
Other projectsSee Past Projects
The Malaria Eradication Scientific Alliance - MESA is dedicated to advancing the science of malaria eradication.http://www.malariaeradication.org/
Study of immune correlates of protection against malaria after vaccination with RTS,S/AS01E: a comprehensive immunological arm of a Phase III double-blind, randomized, controlled multi-center trialhttp://www.sysmalvac.eu/
Mozambican Alliance Towards Elimination of Malaria
Pregnant women as a sentinel group for malaria surveillance in an era of changing malaria transmission
A path towards new diagnostic and prevention tools for severe infectious pathologies
Exploration of the singularities of the sugar nucleotide metabolism and description of novel glycosylation pathways in the malaria parasite
Investigating new aspects of the mechanisms and biological functions of epigenetic variation in malaria parasites
Mechanistic aspects of anemia and splenomegaly caused by plasmodium vivax, a neglected human parasitehttp://www.pvrex.com/
Transforming IPT for optimal pregnancyhttps://www.tiptopmalaria.org
Development of nanovectors for the targeted delivery in Anopheles mosquitoes of agents blocking transmission of Plasmodium parasites
Broad One Health Endectocide-based Malaria Intervention in Africahttp://bohemiaconsortium.org
Unravelling Disease Tolerance and Host Resistance in Afebrile 'P. falciparum' Infections: a Prospective Study in Mozambican Adults
Continued validation of the minimally invasive autopsy for the investigation of the causes of death in infants, and establishment of a research and training center to study causes of death
Measuring community prevalence among HIV exposed children in rural Southern Mozambique
Improving Maternal and Infant Health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant womenwww.mamahproject.net
Infección por virus Zika en mujeres embarazadas que han viajado a zonas afectadas y evaluación de impacto en salud infantil
Improving Care through Azithromycin Research for Infants in Africa