Investigación Publicaciones científicas
Environmental Research 2021;: 110757 -

Polycyclic aromatic hydrocarbons exposures and telomere length: a cross-sectional study on preschool children.

Adli A, Hosseini SM, Najafi ML, Behmanesh M, Ghezi E, Rasti M, Kazemi AA, Rad A, Falanji F, Mohammadzadeh M, Miri M, Dadvand P
22.01.2021
Exposure to polycyclic aromatic hydrocarbons (PAHs) has been associated with shorter telomere length (TL), a marker of ageing at cellular level. However, the available evidence on this association among children is still scarce. We therefore aimed to assess, the relationship between urinary 1-hydroxipayrene (1-OHP), a marker of exposure to PAHs, and relative leukocyte TL (LTL) in children at preschool age. Our study was based on 200 children enrolled from 27 randomly-selected kindergartens in the city of Sabzevar, Iran (2017). 1-OHP levels in the participants' urine samples were measured using solid phase extraction (SPE) method and high-performance liquid chromatography (HPLC). Moreover, real-time PCR was used to measure the LTL in the participants' blood samples. Linear mixed effects models, controlled for relevant covariates, were applied to investigate the association of 1-OHP concentration and LTL. The median (interquartile range (IQR)) of relative LTL and urinary 1-OHP were 0.83 (0.7) and 257 (375.5) ng/L, respectively. In the fully adjusted model, an IQR increase in urinary 1-OHP was related to -0.05 (95% confidence interval (CI): -0.09, -0.01, P-value = 0.02) decrease in relative LTL. This association was similar among boys and girls; however, we observed indications for a stronger association for those children whose parents had university education. Our study suggested an inverse relationship between urinary 1-OHP and LTL in children at preschool age. However, further longitudinal research with repeated measures of PAHs and LTL are needed to confirm these findings. Copyright © 2021 Elsevier Inc. All rights reserved.
Pubmed
https://www.ncbi.nlm.nih.gov/pubmed/?term=33493537
DOI
10.1016/j.envres.2021.110757