DescripciónThe Barcelona Institute for Global Health (ISGlobal) is a cutting-edge institute addressing global public health challenges through research, translation into policy and education. ISGlobal has a broad portfolio in communicable and non-communicable diseases including environmental and climate determinants, and applies a multidisciplinary scientific approach ranging from the molecular to the population level. Research is organized in three main areas, Malaria and other Infectious Diseases, Child and Maternal Health, and Urban Health, Climate & Non-Communicable Diseases. ISGlobal is accredited with the Severo Ochoa distinction, a seal of excellence of the Spanish Science Ministry.
What We Are Looking for
ISGlobal is looking for a motivated phD student to perform his/her thesis in the ATHLETE (Advancing Tools for Human Early Lifecourse Exposome Research and Translation). ATHLETE project has received funding from H2020 (grant agreement 874583) and aims to implement the exposome in birth cohorts in order to study the effects of a wide range of community-level and individual-level environmental risk factors on mental, cardiometabolic, and respiratory health outcomes and associated biological pathways during the first 2 decades of life. In this thesis, we will explore the role of structural variants (CNVs, mosaicisms, genomic inversions and recombination clusters) on neurodevelopmental outcomes and their interaction with the exposome and other omic layers.
Main duties and tasks
The candidate will work mainly with ATHLETE genetics data to link different structural variants with omic data (transcriptomic and epigenomic) and neurodevelopmental outcomes. To this end, the following tasks will be required:
- To call CNV and genetic mosaicisms using raw genetic data
- To call polymorphic inversions and recombination clusters using imputed genotype data
- To assess association between the structural variants and omic data and the exposome
- To assess association between the structural variants and neurodevelopmental outcomes
- To study the effect modification by genetic variation in exposome-neurodevelopmental association
Training and experience
- Degree on Biology, Genetics or equivalent
- Master in Bioinformatics
- Advanced knowledge of R scripting.
- Experience in molecular biology will be valued
- Responsible, flexible and with problem solving skills
- Good organization skills
- Eager to learn and proactive, and with great initiative
- Ability to establish and maintain a good working relationship with people of different national and cultural backgrounds.
- Ability to work as part of a team.
- English, Catalan, Spanish are required.
- Duration:36 months
- Starting date: 15th October 2020
- Contract: full time.
How to apply
Applicants must fill in the request form and include the following code reference position: PREDOCT_ATHLETE_SEP20 attach the CV and a Cover Letter. Each attached document must be named with the candidate name and surname.
The receipt of applications will be open until September, 23rd 2020.
Applications will be accepted until 17.00 CET of the closing date.
Only shortlisted candidates will be contacted.