Asset Publisher

Research & Innovation Programmes

ProCardio

Cardiovascular Risk from Exposure to Low-dose and Low-dose-rate Ionizing Radiation

Duration
2011-2014
Coordinator
Helmholtz Zentrum Munich (HMGU), Munich, Germany, Prof. Mike Atkinson.
Funded by
European Union/Euratom: European Seventh Framework Programm
Epidemiological evidence has established a link between cardiovascular disease and exposure of the heart and major vessels to doses above 500mGy of ionizing radiation. At lower doses the evidence for a detrimental effect is inconclusive. In part, this is due to the lack of appropriate epidemiological studies, coupled with lack of knowledge of the processes involved that is needed for construction of mathematical models.

The ProCardio consortium will study cardiovascular outcomes in childhood cancer survivors where the radiation doses given to the heart can be reconstructed. To maximise the information that can be drawn on this important issue, the Consortium aims to bring together the national studies already ongoing in Europe on existing cohorts of childhood cancer survivors and to set-up an additional cohort in Spain.

The Spanish cohort of childhood cancer survivors (Spanish Childhood Cancer Survivor Study [SPAIN-CCSS] will be established by CREAL in collaboration with the Spanish National Childhood Cancer Registry (RNTI) and the Spanish Society of Paediatric Haematology and Oncology (SEHOP). Following the set-up of SPAIN-CCSS, a case-control study of cardiovascular diseases will be conducted, nested within this cohort. Individual doses to the heart, carotid artery and the main vessels near the dorsal vertebra will be reconstructed from radiotherapy records. Resulting data will be pooled with those of other similar studies ongoing in France and UK, in order to investigate the risk of cardiovascular disease from low to moderate doses of radiation.

Further information about SPAIN CCSS clicking here.

Our Team

Principal Investigator (PI)

Other projects

See Past Projects

MCC-Spain

Population based multicasecontrol study on common tumours in Spain

HELIX

Novel tools for integrating early-life environmental exposures and child health across Europe

EGG/EAGLE

Early Genetics Growth/Early Genetics and Lifecourse Epidemiology

PACE

Pregnancy and Childhood Epigenetics

LIFECYCLE

Early-life stressors and LifeCycle health

OMEGA-NET

Network on the Coordination and Harmonisation of European Occupational Cohorts

HARMONIC

Health effects of cArdiac fluoRoscopy and mOdern radIotherapy in paediatriCs

Mobilise-D

Connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement

EARLY-ADAPT

Signs of Early Adaptation to Climate Change

COVICAT

Cohorte Covid-19 en Cataluña

ATHLETE

Advancing Tools for Human Early Lifecourse Exposome Research and Translation

CONTENT

Cohort of COVID-19 in Spain: social dynamics, mental health and inequalities

EUCAN-Connect

A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health

OBERON

An integrative strategy of testing systems for identification of EDs related to metabolic disorders

EXPANSE

EXposome Powered tools for healthy living in urbAN SEttings

AURORA 2021

Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics

ONES

Fine Particle Matter, Fetal Growth, and Neurodevelopment: Examining Critical Windows of Susceptibility

AIR-NB

Pre-natal exposure to urban AIR pollution and pre- and post-Natal Brain development

NutinBrain

The role of seafood and nut consumption on human neurodevelopment from pregnancy to adolescence

UrbanKids

Urban and social environment and childhood obesity – a natural moving2health experiment

iGenCO

In-Depth Genomics and Cross-Omics Analysis for Undiagnosed Rare Diseases on a User-Friendly Collaborative Platform

CityExposomeCat

An Exposome Approach to Urban Health: Individualized Environmental Exposure Assessment in an Adults Population Cohort Study (GCAT)

TwinAir

Digital Twins Enabled Indoor Air Quality Management for Healthy Living

UBDPOLICY

The Urban Burden of Disease Estimation for POLICY Making

TOLIFE

Combining Artificial Intelligence and smart sensing TOward better management and improved quality of LIFE in chronic obstructive pulmonary disease

BWater

Drinking Water in Barcelona: Sustainability and Health Impact Assessment

INTERCAMBIO

Interventions to promote mental and physical health in changing working environments due to climate change, sustainable work practices, and in green jobs

intoDBP

Innovative Tools to Control Organic Matter and Disinfection Byproducts in Drinking Water

FINDOOR

FTIR spectroscopy for real-time detection of bacterial outbreaks and the rapid identification of pathogenic serotypes, relapsing infections and antibiotic resistance

OccRF-Health

Occupational exposure to radiofrequency electromagnetic fields: From exposure assessment to study of health in workers and their offspring

EPHOR

Exposome Project for Health and Occupational Research

EXPONIT

Analysing and studying how night shift work affects workers' circadian rhythms and health