Carlota Dobaño Lázaro
Associate Research Professor
Carlota Dobaño is the head of the Malaria Immunology Group and coordinates large multicenter studies on naturally acquired and experimentally immunity to malaria. She is also faculty on MSc Global Health, Vaccinology Module.
In 1992 she graduated in Pharmacy and Pharmacology at the Universitat de Barcelona. In 1994 she completed an MSc in Applied Molecular Biology of Infectious Diseases at the London School of Hygiene and Tropical Medicine, developing her thesis project at Anthony Holder’s lab in the Departament of Parasitology, NIMR, MRC, London. In 1999 she obtained her PhD degree at the laboratory of Jana McBride (University of Edinburgh, Scotland) in the study of immune responses to Plasmodium falciparum, with research work conducted at the Malaria Project and Wellcome Trust Centre, Blantyre, Malawi, in collaboration with Malcolm Molyneux and Terrie Taylor.
During 1999-2002 she was a postdoctoral fellow working on malaria vaccine development at the laboratory of Denise Doolan, Malaria Program, Naval Medical Research Center, USA, directed by Stephen Hoffman. In 2003 she joined ISGlobal and the Manhiça Health Research Centre, Mozambique.
Lines of Research
- Immunogenicity, mode of action, correlates of protection of malaria vaccines and systems biology
- Naturally-acquired immunity to malaria during infancy and pregnancy, including impact of control tools
- Immune responses to controlled human malaria infections
- Determinants of development of the immune system in infants
- Effect of malaria and coinfections on the immune system
- Biomarkers of infection, disease and pathogenesis
- Development of multiplex and multiparametric functional immune assays and analytical tools
- Requena P, Barrios D, Robinson LJ, Samol P, Umbers AJ, Wangnapi R, Ome-Kaius M, Rosanas-Urgell A, Mayor A, López M, de Lazzari E, Arévalo-Herrera M, Fernández-Becerra C, del Portillo H, Chitnis CE, Siba PM, Rogerson S, Mueller I, Bardají A, Menéndez C, Dobaño C. Proinflammatory responses and higher IL-10 production by T cells correlate with protection against malaria during pregnancy and delivery outcomes. J Immunol. 2015 Apr 1;194(7):3275-85. doi: 10.4049/jimmunol.1401038.
- Campo JJ, Aponte JJ, Skinner J, Nakajima R, Molina DM, Liang L, Sacarlal J, Alonso PL, Crompton PD, Felgner PL, Dobaño C. RTS,S vaccination is associated with serologic evidence of decreased exposure to Plasmodium falciparum liver- and blood-stage parasites. Mol Cell Proteomics. 2015 Mar;14(3):519-31. doi: 10.1074/mcp.M114.044677.
- Requena P, Campo JJ, Umbers AJ, Ome M, Wangnapi R, Barrios D, Robinson LJ, Samol P, Rosanas-Urgell A, Ubillos I, Mayor A, López M, de Lazzari E, Arévalo-Herrera M, Fernández-Becerra C, del Portillo H, Chitnis CE, Siba PM, Bardají A, Mueller I, Rogerson S, Menéndez C, Dobaño C. Pregnancy and malaria exposure are associated with changes in the B cell pool and in plasma eotaxin levels. J Immunol. 2014 Sep 15;193(6):2971-83. doi: 10.4049/jimmunol.1401037.
- Zhang G, Manaca MN, McNamara-Smith M, Mayor A, Nhabomba A, Berthoud TK, Khoo SK, Wiertsema S, Aguilar R, Barbosa A, Quintó L, Candelaria P, Schultz EN, Hayden CM, Goldblatt J, Guinovart C, Alonso PL, Lesouëf PN, Dobaño C. Interleukin-10 (IL-10) polymorphisms are associated with IL-10 production and clinical malaria in young children. Infect Immun. 2012 Jul;80(7):2316-22. doi: 10.1128/IAI.00261-12.
- Doolan DL, Dobaño C, Baird JK.Acquired immunity to malaria. Clin Microbiol Rev. 2009 Jan;22(1):13-36, Table of Contents. doi: 10.1128/CMR.00025-08. Review. PMID: 19136431
ORCID ID: 0000-0002-6751-4060
RESEARCHER ID: N-4119-2014
SCOPUS ID: 6506513895